News

Breaking Science - Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation

Proximal tubule cells

Check out the new study by CCMBM members, Wenhan Chang, Christian Santa Maria, Zhiqiang Cheng, and Skeletal Biology and Biomechanics Core Managers Chia-Ling Tu and Nicholas Szeto: doi.org/10.1126/scisignal.abc5944. With their coauthors, they elegantly show the importance of precise spatial localization of PTH receptor signaling within distinct subcellular compartments, a discovery that could improve rational drug design to treat osteoporosis. Their findings also have implications for understanding signaling by other G-protein coupled receptors – and the drugs that target them for diseases ranging from to hypertension to diabetes. 

 

Congratulations to Members on their CCMBM Awards

Nafisa Elghazali

Nafisa Elghazali

PhD Candidate

Department of Bioengineering and Therapeutic Sciences

Award: Junior Investigator Travel to ORS ISFR Meeting in Tampa, Florida (Feb 2022)

Lazaros Lataniotis

Lazaros Lataniotis, PhD

Postdoctoral Fellow

Department of Neurology

Award: Junior Investigator Travel to the Emerging Cellular Therapies/Keystone Symposia in British Colombia, Canada (February 2022)

​​​​Saghi Sadoughi

Saghi Sadoughi, PhD

Postdoctoral Researcher

Department of Radiology and Biomedical Imaging

Project: Establishing Time-Lapse HR-pQCT technique for Determining Total Bone Turnover in Patients with CKD 

Award: Tools & Technology

Liping Wang, MD, PhD

Assistant Professional Researcher

Department of Medicine

Project: Spatial Profiling WNT Signaling Pathway in PTH-treated Mouse Bones

Award: Tools & Technology

 

ASBMR CCMBM Roundup

ASBMR-CCMBM Roundup

We would like to recognize CCMBM members who participated and/or received awards during the October 2021 ASBMR Annual meeting in San Diego, California. Congratulations to the following:

 

ASBMR 2021 William F. Neuman Award

Steve Cummings, MD
 

ASBMR 2021 Annual Meeting Most Outstanding Basic Science Abstract Award*

Neha Dole, PhD

We are delighted to have over 40 members attend ASBMR, representing both UCSF and the CCMBM. Read more below about each member’s participation.  

 

Tamara Alliston, PhD
Oral Presentations: Osteocytes - Ablating osteocytic TGFβ signaling mitigates the effects of obesity on systemic energy balance and bone quality

Musculoskeletal Aging Poster - The Role of TGFβ-regulated Osteocytic Perilacunar/canalicular Remodeling in Age-related Bone Fragility

Virtual Plenary Poster Presentations: Osteocytes - miR-181a/b coordinates osteocytic energy metabolism

 

Muriel Babey, MD
Bone Interactions with Other Tissues - Interplay Between High Fat Diet and High Bone Mass In An Estrogen-Responsive Female Neuroskeletal Circuit

Clinical Case Report Poster - Perplexing Case of Parathyroid Hormone (PTH) Resistance vs Hyposecretion: Pseudohypoparathyroidism Type 1B with Minimally Elevated PTH Levels

 

Dennis Black, PhD
Oral Presentations: Nutrition, Physical Activity, and Bone Health - Supplemental Vitamin D Did Not Reduce Incident Fractures in Women and Men in the VITamin D and OmegA-3 TriaL (VITAL)Oral Presentations: Advances in Osteoporosis Treatment - Validation of the Surrogate Threshold Effect as a Method to Implement Change in BMD as a Surrogate Endpoint for Fracture Outcomes: the FNIH-ASBMR SABRE Project

Late-Breaking Oral Presentations: Clinical Treatment - Diabetes mellitus and the benefit of antiresorptive therapy on fracture risk: an FNIHASBMR SABRE study pooled analysis.

Osteoporosis: Treatment (Anabolic) Poster - The effects of Parathyroid hormone and Alendronate alone or in combination on trabecular and cortical bone using DXA-based 3D modelling

Osteoporosis: Treatment (Anti-Resorptive) Poster - Anatomic Location of Atypical Femoral Fractures: A Nationwide Danish Analysis with Blinded Radiographic Review

Osteoporosis: Nutrition, Dietary Supplements and Physical Activity Poster - Prebiotic Intervention to Improve Calcium Absorption in Postmenopausal Women After Gastric Bypass: A Randomized Controlled Trial

Osteoporosis: Treatment (Anti-Resorptive) Poster & Clinical Oral Poster Session II - A Prospective Open-Label Observational Study Of a Buffered Soluble 70 mg Alendronate Effervescent Tablet On Upper Gastrointestinal Safety and Medication Errors: the GastroPASS Study

 

Dan Bikle, MD
Oral Presentations: Bone Interactions with other Tissues - Abaloparatide Promotes Bone Formation At All Sites during Fracture Repair

Virtual Plenary Poster Presentations: Osteoarthritis and Other Joint Disorders - Physicochemical properties and Regulation of IGF-1 Signaling in Osteophytes

Virtual Plenary Poster Presentations: Preclinical Models of Musculoskeletal Disorders - Abaloparatide Directs the Fate of Osteoblast Progenitors during Fracture Repair

 

Andrew Burghardt
2021 Abstract Reviewers

Bone Acquisition and Pediatric Bone Disorders Poster - Comparison of Cortical Bone Outcomes in the Metaphysis and Diaphysis During Growth and Development

Biomechanics and Bone Quality Poster - Second-Generation HR-pQCT Accuracy and Cross-Calibration Study

Bone Acquisition and Pediatric Bone Disorders Poster - Low areal bone mineral density in early pubertal transgender and gender diverse youth is associated with lower peripheral bone strength due to thinner cortices and lower trabecular density

Basic Oral Poster - Comparison of Cortical Bone Outcomes in the Metaphysis and Diaphysis During Growth and Development

Virtual Plenary Poster Presentations: Hormonal Regulators - Biochemical Markers of Bone Turnover in Older Adults with Type 1 Diabetes

 

Peggy Cawthon, PhD, MPH
2021 Program Advisory Committee

2021 Abstract Reviewers

Finance Committee

Oral Presentations: Nutrition, Physical Activity, and Bone Health - Supplemental Vitamin D Did Not Reduce Incident Fractures in Women and Men in the VITamin D and OmegA-3 TriaL (VITAL)

Meet the Professors Session - Advances in Sarcopenia and Assessment

Oral Presentations: Osteoporosis - Risk Assessment, Disease Burden, and Service Provision - Strong discordance in factors associated with 5-year risk of fracture vs. 5-year risk of mortality among men aged 80 and older: findings from the Osteoporotic Fractures in Men [MrOS] study

Sarcopenia, Muscle and Falls Poster - VITamin D and OmegA-3 TriaL (VITAL): Effects on Physical Performance Measures

Osteoporosis: Assessment Poster - Breaking Bone Mineral Density (BMD) into Bone Mineral Content (BMC) and Area Provides New Insight into Hip Fracture Risk: Findings from the Osteoporotic Fractures in Men Study (MrOS)

Virtual Plenary Poster Presentations: Musculoskeletal Aging - Muscle Strength and Physical Performance Improve Fracture Risk Prediction in Men beyond Garvan and FRAX: The Osteoporotic Fractures in Men (MrOS) Study

Late-Breaking Virtual Poster Presentation Session: Osteoporosis - Epidemiology - Repeat Bone Mineral Density Measurement and Fracture Prediction in Older Men: Findings from the Osteoporotic Fractures in Men (MrOS) Study

 

Wenhan Chang, PhD

Oral Presentations: Bone Interactions with other Tissues - Enhanced Skeletal Anabolism by Concurrently Targeting The Parathyroid Hormone 1 Receptor (PTH1R) and Extracellular Calcium-Sensing Receptor (CaSR)

Mineral Metabolism Poster & Basic Oral Poster - FGF23 directly inhibits osteoblast differentiation in DMP1 knockout mice

 

Zhiqiang Cheng, PhD

Oral Presentations: Bone Interactions with other Tissues - Enhanced Skeletal Anabolism by Concurrently Targeting The Parathyroid Hormone 1 Receptor (PTH1R) and Extracellular Calcium-Sensing Receptor (CaSR)

 

Steve Cummings, MD

Oral Presentations: Fracture - Risk and Repair - Artificial intelligence-driven hip fracture prediction based on pelvic radiographs exceeds performance of DXA: the “Study of Osteoporotic Fractures” (SOF)

Poster Session & Basic Oral Poster Session I - Hormonal Regulators - Evaluation of Relugolix Combination Therapy and Bone Mass in Women with Endometriosis-associated Pain Through 52 Weeks: SPIRIT Long-Term Extension Study

Virtual Poster Presentations - Hormonal Regulators - Relugolix Combination Therapy Minimizes Bone Loss in Patients with Endometriosis-associated Pain: Results from the Phase 3 SPIRIT Program

Virtual Poster Presentations - Hormonal Regulators - A Prospective Observational Study of Bone Mineral Density in Premenopausal Women with Endometriosis

 

Neha Dole, PhD

2021 Abstract Reviewer

Early Stage Investigator Subcommittee

*Oral Presentations: Osteocytes - Ablating osteocytic TGFβ signaling mitigates the effects of obesity on systemic energy balance and bone quality

Musculoskeletal Aging Poster - The Role of TGFβ-regulated Osteocytic Perilacunar/canalicular Remodeling in Age-related Bone Fragility

 

Candice Herber, PhD

Oral Presentations: Bone Interactions with other Tissues - A Brain Dependent Osteogenic Factor Controls Peak Bone Mass

Bone Interactions with Other Tissues - Interplay Between High Fat Diet and High Bone Mass In An Estrogen-Responsive Female Neuroskeletal Circuit

 

Sunita Ho, PhD

Virtual Plenary Poster Presentations: Osteoarthritis and Other Joint Disorders - Physicochemical properties and Regulation of IGF-1 Signaling in Osteophytes

 

Edward Hsiao, MD

Oral Presentations: Rare Bone Disease (Clinical) - Palovarotene for the Treatment of Fibrodysplasia Ossificans Progressiva in Females Aged >=8 Years and Males Aged >=10 Years: Data From the Phase III Move Trial

Clinical Oral Poster Session I - Palovarotene for the Treatment of Fibrodysplasia Ossificans Progressiva in Females Aged =8 Years and Males Aged =10 Years: Data From the Phase III Move Trial

Virtual Plenary Poster Presentations - Rare Bone Diseases: Clinical - Greater Heterotopic Ossification Burden Is Associated with Reduced Mobility, Function, and Quality of Life in Individuals with FOP

Virtual Plenary Poster Presentations - Rare Bone Diseases: Clinical - Efficacy of Palovarotene in Patients Who Transferred From a Fibrodysplasia Ossificans Progressiva Natural History Study to the Phase III MOVE Trial

Virtual Plenary Poster Presentations - Rare Bone Diseases: Clinical - A Global Natural History Study (NHS) of Fibrodysplasia Ossificans Progressiva (FOP): Normal Long Bone Growth and Abnormalities in Younger Patients over 36 Months

 

Holly Ingraham, PhD

Oral Presentations: Bone Interactions with other Tissues - A Brain Dependent Osteogenic Factor Controls Peak Bone Mass

Bone Interactions with Other Tissues - Interplay Between High Fat Diet and High Bone Mass In An Estrogen-Responsive Female Neuroskeletal Circuit

 

Serra Kaya, PhD

Oral Presentations: Osteocytes - Ablating osteocytic TGFβ signaling mitigates the effects of obesity on systemic energy balance and bone quality

Musculoskeletal Aging Poster - The Role of TGFβ-regulated Osteocytic Perilacunar/canalicular Remodeling in Age-related Bone Fragility

 

Galateia J. Kazakia, PhD

Biomechanics and Bone Quality Poster - Second-Generation HR-pQCT Accuracy and Cross-Calibration Study

Musculoskeletal Aging Poster - Effects of Age and Osteocyte Dysfunction on Bone Structural Changes During Hindlimb Unloading and Reloading in Mice

Virtual Plenary Poster Presentations: Osteoporosis - Secondary Osteoporosis - Spatial Homogeneity of Bone Marrow Adiposity is Increased in the Proximal Femur of People Living with HIV

Virtual Plenary Poster Presentations: Osteoporosis - Secondary Osteoporosis - Associations of Bone Marrow Adiposity with Trabecular Bone Mineral Density and Microarchitecture are Altered in the Proximal Femur of People Living with HIV

 

Tiffany Kim, MD

Osteoporosis - Nutrition, Dietary Supplements and Physical Activity Poster - Prebiotic Intervention to Improve Calcium Absorption in Postmenopausal Women After Gastric Bypass: A Randomized Controlled Trial

 

Eileen Koh, MD

Virtual Plenary Poster Presentations: Clinical Case Report - Localizing Parathyromatosis via 18F-Fluorocholine Positron Emission Tomography (PET) Neck Magnetic Resonance Imaging (MRI) in a Patient with an Activating GCM2 (glial cell missing 2) Mutation and Familial Isolated Hyperparathyroidism (HPT)

 

Roland Krug, PhD

Osteoporosis: Assessment Poster - MRI-based Vertebral Proton Density Fat Fraction Texture Analysis Predicts CT-based Bone Mineral Measurements

Virtual Plenary Poster Presentations: Osteoporosis - Secondary Osteoporosis - Spatial Homogeneity of Bone Marrow Adiposity is Increased in the Proximal Femur of People Living with HIV

Virtual Plenary Poster Presentations: Osteoporosis - Secondary Osteoporosis - Associations of Bone Marrow Adiposity with Trabecular Bone Mineral Density and Microarchitecture are Altered in the Proximal Femur of People Living with HIV

 

Janet Lee, MD

Bone Acquisition and Pediatric Bone Disorders Poster - Low areal bone mineral density in early pubertal transgender and gender diverse youth is associated with lower peripheral bone strength due to thinner cortices and lower trabecular density

 

Thomas Link, MD, PhD

Virtual Plenary Poster Presentations: Osteoporosis - Secondary Osteoporosis - Spatial Homogeneity of Bone Marrow Adiposity is Increased in the Proximal Femur of People Living with HIV

Virtual Plenary Poster Presentations: Osteoporosis - Secondary Osteoporosis - Associations of Bone Marrow Adiposity with Trabecular Bone Mineral Density and Microarchitecture are Altered in the Proximal Femur of People Living with HIV

 

Sharmila Majumdar, PhD

Symposium: A Look to the Future: Advances and Challenges in Clinical Bone Research - A Look to the Future: Advances and Challenges in Clinical Bone Research Artificial Intelligence and Imaging for an Integrated Approach to Musculoskeletal Aging

 

Ralph Marcucio, PhD

Oral Presentations: Bone Interactions with other Tissues - A Brain Dependent Osteogenic Factor Controls Peak Bone Mass

 

Kazu Morioka, PhD

Oral Presentations: Bone Interactions with other Tissues - A Brain Dependent Osteogenic Factor Controls Peak Bone Mass

 

Robert Nissenson, PhD

Virtual Plenary Poster Presentations - Bone Interactions with the Immune System - Progranulin Limits the Osteogenic Effect of Bone Marrow Macrophages

Virtual Plenary Poster Presentations - Preclinical Models of Musculoskeletal Disorders - Abaloparatide Directs the Fate of Osteoblast Progenitors during Fracture Repair

 

Stephen Rosenthal, MD

Bone Acquisition and Pediatric Bone Disorders Poster - Low areal bone mineral density in early pubertal transgender and gender diverse youth is associated with lower peripheral bone strength due to thinner cortices and lower trabecular density

 

Saghi Sadoughi, PhD

Biomechanics and Bone Quality Poster - Second-Generation HR-pQCT Accuracy and Cross-Calibration Study

 

Christian Santa Maria

Oral Presentations: Bone Interactions with other Tissues - Enhanced Skeletal Anabolism by Concurrently Targeting The Parathyroid Hormone 1 Receptor (PTH1R) and Extracellular Calcium-Sensing Receptor (CaSR)

 

Anne Schafer, MD

Education Advisory Committee, Co-Chairperson

Bone Acquisition and Pediatric Bone Disorders Poster - Low areal bone mineral density in early pubertal transgender and gender diverse youth is associated with lower peripheral bone strength due to thinner cortices and lower trabecular density

Osteoporosis - Nutrition, Dietary Supplements and Physical Activity Poster - Prebiotic Intervention to Improve Calcium Absorption in Postmenopausal Women After Gastric Bypass: A Randomized Controlled Trial

 

Charles Schurman

Musculoskeletal Aging Poster - The Role of TGFβ-regulated Osteocytic Perilacunar/canalicular Remodeling in Age-related Bone Fragility

 

Ann Schwartz, MD

Late-Breaking Oral Presentations: Clinical Treatment - Diabetes mellitus and the benefit of antiresorptive therapy on fracture risk: an FNIHASBMR SABRE study pooled analysis

Virtual Plenary Poster Presentations: Hormonal Regulators - Biochemical Markers of Bone Turnover in Older Adults with Type 1 Diabetes

 

Dolores Shoback, MD

2021 Program Advisory Committee

Diversity, Equity, and Inclusion Committee

Plenary session reviewing the most impactful clinical and basic science

Oral Presentations: Bone Interactions with other Tissues - Enhanced Skeletal Anabolism by Concurrently Targeting The Parathyroid Hormone 1 Receptor (PTH1R) and Extracellular Calcium-Sensing Receptor (CaSR)

Annual Review of Bone, Mineral and Musculoskeletal Research - Clinical Science Review

Late-Breaking Oral Presentation: Clinical Hyoparathyroidism and Hypeparathyroidism Guidelines - Guidelines on Diagnosis, Evaluation and Management of Hypoparathyroidism: 2021

Clinical Case Report Poster - Perplexing Case of Parathyroid Hormone (PTH) Resistance vs Hyposecretion: Pseudohypoparathyroidism Type 1B with Minimally Elevated PTH Levels

Virtual Plenary Poster Presentations: Clinical Case Report - Localizing Parathyromatosis via 18F-Fluorocholine Positron Emission Tomography (PET) Neck Magnetic Resonance Imaging (MRI) in a Patient with an Activating GCM2 (glial cell missing 2) Mutation and Familial Isolated Hyperparathyroidism (HPT)

 

Spenser Smith, PhD

Osteoblasts Poster - miR-433-3p Suppresses Bone Formation and mRNAs Critical for Osteoblast Function in Mice

 

Nico Sollmann, MD, PhD

Osteoporosis: Assessment Poster - MRI-based Vertebral Proton Density Fat Fraction Texture Analysis Predicts CT-based Bone Mineral Measurements

 

Liping Wang, MD, PhD

Oral Presentations: Bone Interactions with other Tissues - Abaloparatide Promotes Bone Formation At All Sites during Fracture Repair

Virtual Plenary Poster Presentations - Bone Interactions with the Immune System - Progranulin Limits the Osteogenic Effect of Bone Marrow Macrophages

Virtual Plenary Poster Presentations - Preclinical Models of Musculoskeletal Disorders - Abaloparatide Directs the Fate of Osteoblast Progenitors during Fracture Repair

 

Yongmei Wang, MD, PhD

Virtual Plenary Poster Presentations: Osteoarthritis and Other Joint Disorders - Physicochemical properties and Regulation of IGF-1 Signaling in Osteophytes

 

Kelly Wentworth, MD

ASBMR/ECTS Clinical Debate - For the Motion: Intermittent Drug Holidays are Mandatory for Long Term Bisphosphonate Treatment of Osteoporosis?

Industry Supported Symposium: Managing Fibrodysplasia Ossificans Progressiva (FOP): Therapeutic Advances

 

Karin Wu, MD

Osteoporosis - Nutrition, Dietary Supplements and Physical Activity Poster - Prebiotic Intervention to Improve Calcium Absorption in Postmenopausal Women After Gastric Bypass: A Randomized Controlled Trial

 

Po-Hung Wu, PhD

Biomechanics and Bone Quality Poster - Second-Generation HR-pQCT Accuracy and Cross-Calibration Study

Musculoskeletal Aging Poster - Effects of Age and Osteocyte Dysfunction on Bone Structural Changes During Hindlimb Unloading and Reloading in Mice

Virtual Plenary Poster Presentations: Osteoporosis - Secondary Osteoporosis - Spatial Homogeneity of Bone Marrow Adiposity is Increased in the Proximal Femur of People Living with HIV

Virtual Plenary Poster Presentations: Osteoporosis - Secondary Osteoporosis - Associations of Bone Marrow Adiposity with Trabecular Bone Mineral Density and Microarchitecture are Altered in the Proximal Femur of People Living with HIV

 

Cristal Yee, PhD

Oral Presentations: Osteocytes - Ablating osteocytic TGFβ signaling mitigates the effects of obesity on systemic energy balance and bone quality

 

Jihee Yoon

Oral Presentations: Osteocytes - Ablating osteocytic TGFβ signaling mitigates the effects of obesity on systemic energy balance and bone quality

Virtual Plenary Poster Presentations: Osteocytes - miR-181a/b coordinates osteocytic energy metabolism