News
The CCMBM leadership team is excited to announce that we have been awarded another five-year cycle for our P30 grant from NIH/NIAMS. This award supports continuation of the Core Center for Musculoskeletal Biology and Medicine (CCMBM) and the funding and services it provides to our musculoskeletal community. Thanks to your success and involvement, reviewers praised CCMBM for stimulating collaborative publications by 28%, increasing membership by 41%, and fostering a 2.4x increase in grant funding to CCMBM members.
The new P30 enables the CCMBM to continue supporting and growing a robust musculoskeletal research community at UCSF and throughout the UC system. In addition to core services, seminars and workshops, and funding for musculoskeletal research, new initiatives for this next funding cycle include expansion of computational and data science resources for CCMBM members and growth of the UC STRETCH program. Stay tuned for more. Cheers!
We are excited to host the above upcoming seminars and bring speakers to the UCSF community this 2024-2025 academic year. CCMBM members, including junior investigators, trainees and learners, have priority to meet with visiting faculty speakers. The CCMBM Seminar Committee will provide scheduling details as we near each speaker’s visit. Contact Pui Yee Law if you would like us to consider and invite potential speakers to visit UCSF.
Bethany Andoko
Junior Specialist
Department of Orthopaedic Surgery
Award: JIC Grant Development Award
Verima Pereira, PhD
Postdoctoral Fellow
Department of Hematology & Oncology
Award: JIC Grant Development Award
Betsy Young, MD
Instructor
Department of Pediatrics
Award: JIC Grant Development Award
The UCSF MSK Community Convenes for "Fueling MSK Health & Discovery with Data Science, Technology, and Digital Health"
This year, the NIH P30 Core Center for Musculoskeletal Biology and Medicine (CCMBM) hosted attendees in person and online for their annual retreat. Co-sponsored with the UCSF Department of Orthopaedic Surgery, Fueling MSK Health & Discovery with Data Science, Technology, and Digital Health drew 175 attendees to join the 39 invited speakers and moderators during March 12-13, 2024.
The first day of the retreat opened with talks from two keynote speakers. Rob Reich, PhD, Professor of Political Science at Stanford University presented on “Governance of Emerging Technologies: The Case of AI Norms, Standards, and Policies.” This was followed by a talk from Anita Ho, PhD, MPH, Associate Professor at the UCSF Bioethics Program titled “Deep Ethical Learning in the Evolving AI Landscape for MSK Health.” Both speakers engaged in a lively panel discussion moderated by Marc Kohli, MD, Professor of Radiology and Biomedical Imaging at UCSF. The evening concluded with cake and a champagne toast celebrating the CCMBM’s 10th anniversary.
The second day began with introductory remarks from Tamara Alliston, PhD, followed by a fireside chat with UCSF Chancellor Sam Hawgood, MBBS. The rest of the morning consisted of sessions on basic and clinical science featuring Bradford Distinguished Lectureship Speaker Marina Sirota, PhD, who gave a talk titled “From Bulk to Single Cell Signals: Using Data to Understand Autoimmune Disease in the Era of Precision Medicine.”
The afternoon keynote was given by Susan Gregurick, PhD, who gave a talk on the NIH’s data science strategy titled “AI for Health and Research: Exploring NIH’s Strategies, Challenges, and Vision for the Future.” The day concluded with a data science resources practicum session featuring presentations from various UCSF centers including the Center for Intelligent Imaging, Radiology Research Support Services, Academic Research Services, Versa AI, and the Data Sciences CoLab.
Throughout both days, attendees also heard short slam and lightning talks from UCSF trainees, CCMBM grantees, and CCMBM STRETCH scholars. With a total of 10 slam talks and 4 lightning talks, this year’s retreat featured a variety of exciting research from emerging scholars.
Congratulations to the Poster and Slam Talk Winners!
Outstanding CCMBM Slam Talk – Christoforos Meliadis, MD, Exercise for Hearing Longevity
CCMBM Slam Talk, Second Place – Madeline Hess, Deep Learning Brings Faster MRI Scanning and Automatic Image Analysis to UCSF and Patients: Clinical Translation of DL-Based Research Models at UCSF
Outstanding CCMBM Postdoctoral Poster – Eva Gonzalez Diaz, PhD, The Gut Microbiome Regulates Osteocyte Transcription in a Sexually Dimorphic Manner
Outstanding CCMBM Predoctoral Poster – Chongshan Liu, Recovering Bone Tissue Strength Through Fecal Microbiota Transplantation in Adult Mice
CCMBM Postdoctoral Poster, Second Place – Mitsuhiro Nishizawa, MD, Antibacterial Properties of Ultrafine-grained Biomaterials
CCMBM Predoctoral Poster, Second Place – Luke Sang, Mitochondrial Transfer For Muscle Regeneration Following Ischemia Reperfusion Injury
The CCMBM would like to thank our Event Sponsors:
- UCSF Department of Orthopaedic Surgery
- Dr. David Bradford Lectureship Fund
- UCSF Department of Physical Therapy and Rehabilitation Science
- Center for Disruptive Musculoskeletal Innovations (CDMI)
- UCSF Department of Radiology and Biomedical Imaging
- UCSF Musculoskeletal Center
Kudos to the Scientific Retreat Committee: Victor Cheuy, PhD, Event Chair; Galateia Kazakia, PhD, Event Co-Chair; Tamara Alliston, PhD; Noah Bonnheim, PhD; Kelsey Collins, PhD; Eva Gonzalez Diaz, PhD; Serra Kaya, PhD; Gurcharan Kaur, PhD; Pui Yee Law; Tom Sullivan
Joe Darryl Baal, MD
Resident
Department of Radiology & Biomedical Imaging
Award: JIC Travel Award
March 2024 - European Congress of Radiology
Laura Chen
Clinical Research Coordinator
Department of Radiology & Biomedical Imaging
Award: JIC Travel Award
April 2024 - OARSI World Congress on Osteoarthritis
Priscilla Tjandra, PhD
Postdoctoral Scholar
Department of Orthopaedic Surgery
Award: JIC Travel Award
May 2024 - PURPOSE Annual Meeting
Hannah Greenfeld, PhD
Postdoctoral Scholar
Department of Obstetrics, Gynecology, and Reproductive Science
Award: JIC Travel Award
July 2023 – 12th European Zebrafish Meeting
Rozana Shemirani
Graduate Student
Department of Oral & Craniofacial Sciences
Award: JIC Travel Award
October 2023 – American Society for Bone and Mineral Research
Verima Pereira, PhD
Postdoctoral Fellow
Department of Hematology and Oncology
Award: JIC Travel Award
October 2023 - ACS Outreach Summit
Bethany Andoko
Junior Specialist
Collins Lab, Department of Orthopaedic Surgery
Award: JIC Grant Development Award
Brian Feeley, MD
Professor
Department of Orthopaedic Surgery
Project: "Cellular heterogeneity and sex based differences in human ACL injuries"
Award: RAP Pilot & Feasibility Grant (CCMBM/REAC)
Daehyun Yoon, PhD
Assistant Professor
Department of Radiology and Biomedical Imaging
Project: “Ultra-short Echo Time MRI for Aiding in the Detection of Vessels in Cortical Bone Pore Space”
Award: Tools & Technology Grant
We are excited to host the above upcoming seminars and bring speakers to the UCSF community this 2023-2024 academic year. CCMBM members, including junior investigators, trainees and learners, have priority to meet with visiting faculty speakers. The CCMBM Seminar Committee will follow up with scheduling details as we near each speaker’s visit. Contact Pui Yee Law if you would like us to consider and invite potential speakers to visit UCSF.
Sign up early to receive Outlook invites for future Hot Talks, Cool Science seminars!
Karsyn Bailey
MD/PhD Student
Alliston Lab, Department of Orthopaedic Surgery
Award: JIC Travel Award
February 2023 - Orthopaedic Research Society Annual Meeting
Daniel Bikle, MD, PhD
Professor of Medicine and Dermatology
School of Medicine
Project: "The impact of abaloparatide on stem cell function during fracture repair"
Award: RAP Pilot & Feasibility (REAC)
Noah Bonnheim, PhD
Postdoctoral Scholar
Fields Lab, Department of Orthopaedic Surgery
Project: "Biochemical mechanisms affecting T1ρ relaxation times in the intervertebral disc"
Award: Tools & Technology Grant
Sanjay Ghosh, PhD
Postdoctoral Scholar
Kazakia Lab, Department of Radiology and Biomedical Imaging
Project: "Machine learning methods for denoising and fusion of mask musculoskeletal images”
Award: JIC Grant Development Award
Sunita Ho, MS, PhD
Professor of Preventative and Restorative Dental Science
School of Dentistry
Project: "Sustainable partnership through correlative workflows between the BBCMC and the BIDC imaging facilities"
Award: RAP Pilot & Feasibility Grant (COIA)
Jae-Young Jung, PhD
Postdoctoral Scholar
Fields Lab, Department of Orthopaedic Surgery
Award: JIC Travel Award
March 2023 - The Minerals, Metals & Materials Society (TMS) Annual Meeting
Tiffany Kim, MD
Assistant Professor of Medicine
SFVAMC Staff Physician
Project: "Bone marrow fat and skeletal health in type 2 diabetes"
Award: RAP Pilot & Feasibility Grant (CCMBM)
Rachael Stovall, MD
Clinical Fellow
Rheumatology, Department of Medicine
Award: JIC Travel Award
May 2023 - SPARTAN Annual Meeting
An Vu, PhD
Assistant Professor of Radiology
Department of Radiology and Biomedical Imaging
Project: "Integration of markerless motion correction and high-temporal resolution technologies for fast, robust, sub-millimeter gSLIDER fMRI at 3T"
Award: RAP Pilot & Feasibility Grant (Academic Senate)
CCMBM leadership, faculty, and staff, spent much of the spring hard at work on the center's P30 renewal application and progress report. Thank you for your support of the application in completing the surveys and providing biosketches customized for the CCMBM. Now that it has been submitted, we wanted to share some of the most exciting facts and figures from the report.
CCMBM membership grew from 114 to 161 (41%).
Grant funding to CCMBM investigators increased 2.4x from $65M to $156M.
CCMBM investigators authored over 550 MSK-related research publications.
The number of publications coauthored by CCMBM investigators increased by 28%.
This year, the NIH P30 Core Center for Musculoskeletal Biology and Medicine (CCMBM) hosted attendees in person and online for their annual retreat. Co-sponsored with the UCSF Department of Orthopaedic Surgery and REACH, A Picture of Pain: Advances in Management and Treatment drew over 150 attendees to join the 23 invited speakers and moderators during February 28-March 1, 2023.
The first day of the retreat opened with a talk from keynote speaker Kate Nicholson, JD, Founder and Executive Director of the National Pain Advocacy Center (NPAC) titled “Advocacy, Equity, and the Lived Experience of Pain.” This was followed by a panel discussion featuring members of the Integrated Pain Team at the San Francisco VA Medical Center and a slam talk competition featuring five UCSF trainees. Orthopaedic Surgery Resident Steven Garcia, MD, took home this year's prize for Best Slam Talk.
The second day began with sessions on the intersection of pain science and musculoskeletal biology featuring Bradford Distinguished Lectureship Speaker Adam Goode, PT, DPT, PhD, who gave a talk titled “Musculoskeletal Pain Phenotypes and Personalized Value-Based Health Care.” Attendees also heard from Kathleen Sluka, PT, PhD, FAPTA, whose morning keynote focused on "The Science of Exercise-Induced Pain and Analgesia."
In the afternoon, UCSF’s principal ergonomist Kristin Amlie led a guided ergonomics session, and the retreat concluded with a closing keynote from Helene M. Langevin, MD, Director of the National Center for Complementary and Integrative Health (NCCIH), who spoke on “A Whole Person Approach to Pain Research.”
Congratulations to the Poster and Slam Talk Winners!
Best Slam Talk – Steven Garcia, MD, DLK1 prevents human fibroadipogenic cell adipogenesis
Best Postdoctoral Scholar/Resident Poster – Steven Garcia, MD, Distinct Human Fibroadipogenic Progenitor Cell Populations from Healthy and Injured Skeletal Muscle
Second Place Postdoctoral Scholar/Resident Poster – Zuzana Vavrusova, PhD, Comparative Developmental Morphospace of Embryonic Brain and Face Growth in Chicken, Mouse, and Human Reveals Novel Allometric Shifts
Best Trainee Poster – Jessica Ornowski, Validity of automated clinical MRI thresholding approaches for predicting fat infiltration of the paraspinal muscles
Second Place Trainee Poster – Rachael Stovall, MD, Incidence Rate and Factors associated with Fractures among Adults with Ankylosing Spondylitis in the United States
The CCMBM would like to thank our Event Sponsors:
- Core Center for Patient-centric, Mechanistic Phenotyping in Chronic Low Back Pain (REACH)
- UCSF Department of Orthopaedic Surgery
- UCSF Department of Physical Therapy and Rehabilitation Science
- UCSF Department of Radiology and Biomedical Imaging
- Dr. David Bradford Lectureship Fund
Kudos to the Scientific Retreat Committee: Galateia Kazakia, PhD, and Victor Cheuy, PhD, Event Co-Chairs; Tamara Alliston, PhD; Jeannie Bailey, PhD; Upasana Bharadwaj, MD; Noah Bonnheim, PhD; Nicholas Hanne, PhD; Jerry Jung, PhD; Serra Kaya, PhD; Pui Yee Law; Jeffrey Lotz, PhD; Conor O’Neill, MD; Jessica Ornowski; Irina Strigo, PhD; Tom Sullivan; Jake Williams; Kaitlin Yee
2022-2023 Seminar Series
We are excited to host the upcoming fall/winter seminars and bring speakers to the UCSF community. CCMBM members, including junior investigators, have priority to meet with visiting faculty speakers. Take the poll to let us know your meeting preferences. The CCMBM Seminar Committee will follow up with scheduling details as we near each speaker’s visit. Contact Pui Yee Law if you would like us to invite potential speakers for 2023 spring and summer.
Postdoctoral Scholar
Fields Lab, Department of Orthopaedic Surgery
Award: Junior Investigator Travel Award
June 2022 - Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C)
Postdoctoral Scholar
Kazakia Lab, Department of Radiology and Bioimaging
Award: Junior Investigator Travel Award
Sept 2022 – American Society for Bone and Mineral Research
Vice Chair for Research and Professor
Department of Physical Therapy and Rehabilitation Science
Project: The Relationship between Gait Biomechanics and Exercise Induced Pain Flares in Patellofemoral Joint Osteoarthritis
Award: Pilot Project (CCMBM)
Postdoctoral Scholar
Young Lab, Department of Orthopaedic Surgery
Award: Junior Investigator Travel Award
July 2022 - Society for Developmental Biology
Spring into Year 2022
As we have sprung into 2022, we are excited offer a robust seminar series, begin new partnerships with other institutions and programs, and support our members and MSK community with their research.
We continuously seek to better understand how to serve you. As such, we are preparing the CCMBM annual member survey in preparation for our annual NIH NIAMS progress report. In advance, we thank you for your feedback. It is crucial for shaping future CCMBM services and programs that will benefit you and your research.
This year the NIH P30 Core Center for Musculoskeletal Biology and Medicine (CCMBM) hosted its annual scientific retreat in a hybrid format welcoming everyone back in-person and through remote participation online. Co-sponsored with UCSF Department of Orthopaedic Surgery, the event entitled The Past, Present, and Future of Aging: Perspectives on Building Longer Healthier Lives drew over 110 attendees to join the 24 invited speakers and moderators during March 15-16, 2022.
During the first day, Steven Petrow, Washington Post columnist and award-winning journalist along with Coleen Sabatini, MD Orthopaedic Surgeon and Professor at UCSF, provided a key conversation on aging and its intersection with musculoskeletal heath. Slam talks were given by three UCSF trainees with Orthopaedic Surgery Resident Ryan Halvorson as the declared winner.
The second day of the retreat featured sessions on the past, present and future of aging with Bradford Distinguished Lectureship Speaker Douglas P. Kiel who gave his keynote on, “Hallmarks of the Aging Skeleton.”
CCMBM Junior Investigator and event committee member Upasana Bharadwaj, MD, led the afternoon’s guided meditation before we concluded the day with the closing keynote from James N. Weinstein, DO, MS, Senior Vice President of Microsoft Health, who spoke on “The Sixth Scientific Paradigm: Big Data Meets Ptolemaic Socioeconomics.”
Congratulations to the Poster Winners!
Best Postdoc Poster - Serra Kaya, PhD, Transcriptomic Analysis of Aged Mouse Bone Identifies Novel Genes Enriched for Genetic Associations with Osteoarthritis in Human
Second Place Trainee Poster - Jessica Ornowski, Validity of Automated T1-weighted Thresholding Approaches for Predicting Fat Infiltration of the Paraspinal Muscles with omparison to Advanced Water-far Sequences
Best Graduate Student Poster - Karsyn Bailey, Mechanosensitive Control of Articular Cartilage and Subchondral Bone Homeostasis Requires Osteocytic TGFβ Signaling
Second Place Graduate Student Poster- Jihee Yoon, miR-181a/b Controls Osteocyte Bioenergetics
The CCMBM would like to thank event Sponsors:
= UCSF Department of Orthopaedic Surgery
= Dr. David Bradford Lectureship Fund
= UCSF Department of Physical Therapy and Rehabilitation Science
= UCSF Department of Radiology and Biomedical Imaging
= Center for Disruptive Musculoskeletal Innovations (CDMI)
Kudos to the Scientific Retreat Committee: Galateia Kazakia, PhD, and Nathan Young, PhD, Event Co-Chairs; Tamara Alliston, PhD; Upasana Bharadwaj, MD; Noah Bonnheim, PhD; Victor Cheuy, PhD; Nicholas Hanne, PhD; Candice Herber, PhD; Sunita Ho, PhD; Jerry Jung, PhD; Pui Yee Law; Mary Tran.
Christine Hong, DMD
Associate Professor
Department of Orofacial Sciences
Project: Role of p75NTR in Osteogenic Differentiation and Skeletal Development using Mouse Models
Award: Pilot/Feasibility (CCMBM)
Kazuhito Morioka, PhD
Assistant Professor
Department of Orthopaedic Surgery
Project: Nociplastic Spinal Cord-Muscle Loop in Degenerative Disc Disease (DDD)
Award: Pilot/Feasibility (CCMBM & Academic Senate)
We are excited to host the upcoming spring seminars and bring speakers to the UCSF community. CCMBM members, including junior investigators, have priority to meet with visiting faculty speakers. CCMBM members, including junior investigators, have priority to meet with visiting faculty speakers. Take the poll to let the Seminar Committee know your meeting preferences. The Committee will follow up with scheduling details as we near each speaker’s visit. Contact Mary Tran if you would like us to invite potential speakers for this coming summer and fall.
Breaking Science - Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation
Check out the new study by CCMBM members, Wenhan Chang, Christian Santa Maria, Zhiqiang Cheng, and Skeletal Biology and Biomechanics Core Managers Chia-Ling Tu and Nicholas Szeto: doi.org/10.1126/scisignal.abc5944. With their coauthors, they elegantly show the importance of precise spatial localization of PTH receptor signaling within distinct subcellular compartments, a discovery that could improve rational drug design to treat osteoporosis. Their findings also have implications for understanding signaling by other G-protein coupled receptors – and the drugs that target them for diseases ranging from to hypertension to diabetes.
Nafisa Elghazali
PhD Candidate
Department of Bioengineering and Therapeutic Sciences
Award: Junior Investigator Travel to ORS ISFR Meeting in Tampa, Florida (Feb 2022)
Lazaros Lataniotis, PhD
Postdoctoral Fellow
Department of Neurology
Award: Junior Investigator Travel to the Emerging Cellular Therapies/Keystone Symposia in British Colombia, Canada (February 2022)
Saghi Sadoughi, PhD
Postdoctoral Researcher
Department of Radiology and Biomedical Imaging
Project: Establishing Time-Lapse HR-pQCT technique for Determining Total Bone Turnover in Patients with CKD
Award: Tools & Technology
Liping Wang, MD, PhD
Assistant Professional Researcher
Department of Medicine
Project: Spatial Profiling WNT Signaling Pathway in PTH-treated Mouse Bones
Award: Tools & Technology
We would like to recognize CCMBM members who participated and/or received awards during the October 2021 ASBMR Annual meeting in San Diego, California. Congratulations to the following:
ASBMR 2021 William F. Neuman Award
Steve Cummings, MD
ASBMR 2021 Annual Meeting Most Outstanding Basic Science Abstract Award*
Neha Dole, PhD
We are delighted to have over 40 members attend ASBMR, representing both UCSF and the CCMBM. Read more below about each member’s participation.
Tamara Alliston, PhD
Oral Presentations: Osteocytes - Ablating osteocytic TGFβ signaling mitigates the effects of obesity on systemic energy balance and bone quality
Musculoskeletal Aging Poster - The Role of TGFβ-regulated Osteocytic Perilacunar/canalicular Remodeling in Age-related Bone Fragility
Virtual Plenary Poster Presentations: Osteocytes - miR-181a/b coordinates osteocytic energy metabolism
Muriel Babey, MD
Bone Interactions with Other Tissues - Interplay Between High Fat Diet and High Bone Mass In An Estrogen-Responsive Female Neuroskeletal Circuit
Clinical Case Report Poster - Perplexing Case of Parathyroid Hormone (PTH) Resistance vs Hyposecretion: Pseudohypoparathyroidism Type 1B with Minimally Elevated PTH Levels
Dennis Black, PhD
Oral Presentations: Nutrition, Physical Activity, and Bone Health - Supplemental Vitamin D Did Not Reduce Incident Fractures in Women and Men in the VITamin D and OmegA-3 TriaL (VITAL)Oral Presentations: Advances in Osteoporosis Treatment - Validation of the Surrogate Threshold Effect as a Method to Implement Change in BMD as a Surrogate Endpoint for Fracture Outcomes: the FNIH-ASBMR SABRE Project
Late-Breaking Oral Presentations: Clinical Treatment - Diabetes mellitus and the benefit of antiresorptive therapy on fracture risk: an FNIHASBMR SABRE study pooled analysis.
Osteoporosis: Treatment (Anabolic) Poster - The effects of Parathyroid hormone and Alendronate alone or in combination on trabecular and cortical bone using DXA-based 3D modelling
Osteoporosis: Treatment (Anti-Resorptive) Poster - Anatomic Location of Atypical Femoral Fractures: A Nationwide Danish Analysis with Blinded Radiographic Review
Osteoporosis: Nutrition, Dietary Supplements and Physical Activity Poster - Prebiotic Intervention to Improve Calcium Absorption in Postmenopausal Women After Gastric Bypass: A Randomized Controlled Trial
Osteoporosis: Treatment (Anti-Resorptive) Poster & Clinical Oral Poster Session II - A Prospective Open-Label Observational Study Of a Buffered Soluble 70 mg Alendronate Effervescent Tablet On Upper Gastrointestinal Safety and Medication Errors: the GastroPASS Study
Dan Bikle, MD
Oral Presentations: Bone Interactions with other Tissues - Abaloparatide Promotes Bone Formation At All Sites during Fracture Repair
Virtual Plenary Poster Presentations: Osteoarthritis and Other Joint Disorders - Physicochemical properties and Regulation of IGF-1 Signaling in Osteophytes
Virtual Plenary Poster Presentations: Preclinical Models of Musculoskeletal Disorders - Abaloparatide Directs the Fate of Osteoblast Progenitors during Fracture Repair
Andrew Burghardt
2021 Abstract Reviewers
Bone Acquisition and Pediatric Bone Disorders Poster - Comparison of Cortical Bone Outcomes in the Metaphysis and Diaphysis During Growth and Development
Biomechanics and Bone Quality Poster - Second-Generation HR-pQCT Accuracy and Cross-Calibration Study
Bone Acquisition and Pediatric Bone Disorders Poster - Low areal bone mineral density in early pubertal transgender and gender diverse youth is associated with lower peripheral bone strength due to thinner cortices and lower trabecular density
Basic Oral Poster - Comparison of Cortical Bone Outcomes in the Metaphysis and Diaphysis During Growth and Development
Virtual Plenary Poster Presentations: Hormonal Regulators - Biochemical Markers of Bone Turnover in Older Adults with Type 1 Diabetes
Peggy Cawthon, PhD, MPH
2021 Program Advisory Committee
2021 Abstract Reviewers
Finance Committee
Oral Presentations: Nutrition, Physical Activity, and Bone Health - Supplemental Vitamin D Did Not Reduce Incident Fractures in Women and Men in the VITamin D and OmegA-3 TriaL (VITAL)
Meet the Professors Session - Advances in Sarcopenia and Assessment
Oral Presentations: Osteoporosis - Risk Assessment, Disease Burden, and Service Provision - Strong discordance in factors associated with 5-year risk of fracture vs. 5-year risk of mortality among men aged 80 and older: findings from the Osteoporotic Fractures in Men [MrOS] study
Sarcopenia, Muscle and Falls Poster - VITamin D and OmegA-3 TriaL (VITAL): Effects on Physical Performance Measures
Osteoporosis: Assessment Poster - Breaking Bone Mineral Density (BMD) into Bone Mineral Content (BMC) and Area Provides New Insight into Hip Fracture Risk: Findings from the Osteoporotic Fractures in Men Study (MrOS)
Virtual Plenary Poster Presentations: Musculoskeletal Aging - Muscle Strength and Physical Performance Improve Fracture Risk Prediction in Men beyond Garvan and FRAX: The Osteoporotic Fractures in Men (MrOS) Study
Late-Breaking Virtual Poster Presentation Session: Osteoporosis - Epidemiology - Repeat Bone Mineral Density Measurement and Fracture Prediction in Older Men: Findings from the Osteoporotic Fractures in Men (MrOS) Study
Wenhan Chang, PhD
Oral Presentations: Bone Interactions with other Tissues - Enhanced Skeletal Anabolism by Concurrently Targeting The Parathyroid Hormone 1 Receptor (PTH1R) and Extracellular Calcium-Sensing Receptor (CaSR)
Mineral Metabolism Poster & Basic Oral Poster - FGF23 directly inhibits osteoblast differentiation in DMP1 knockout mice
Zhiqiang Cheng, PhD
Oral Presentations: Bone Interactions with other Tissues - Enhanced Skeletal Anabolism by Concurrently Targeting The Parathyroid Hormone 1 Receptor (PTH1R) and Extracellular Calcium-Sensing Receptor (CaSR)
Steve Cummings, MD
Oral Presentations: Fracture - Risk and Repair - Artificial intelligence-driven hip fracture prediction based on pelvic radiographs exceeds performance of DXA: the “Study of Osteoporotic Fractures” (SOF)
Poster Session & Basic Oral Poster Session I - Hormonal Regulators - Evaluation of Relugolix Combination Therapy and Bone Mass in Women with Endometriosis-associated Pain Through 52 Weeks: SPIRIT Long-Term Extension Study
Virtual Poster Presentations - Hormonal Regulators - Relugolix Combination Therapy Minimizes Bone Loss in Patients with Endometriosis-associated Pain: Results from the Phase 3 SPIRIT Program
Virtual Poster Presentations - Hormonal Regulators - A Prospective Observational Study of Bone Mineral Density in Premenopausal Women with Endometriosis
Neha Dole, PhD
2021 Abstract Reviewer
Early Stage Investigator Subcommittee
*Oral Presentations: Osteocytes - Ablating osteocytic TGFβ signaling mitigates the effects of obesity on systemic energy balance and bone quality
Musculoskeletal Aging Poster - The Role of TGFβ-regulated Osteocytic Perilacunar/canalicular Remodeling in Age-related Bone Fragility
Candice Herber, PhD
Oral Presentations: Bone Interactions with other Tissues - A Brain Dependent Osteogenic Factor Controls Peak Bone Mass
Bone Interactions with Other Tissues - Interplay Between High Fat Diet and High Bone Mass In An Estrogen-Responsive Female Neuroskeletal Circuit
Sunita Ho, PhD
Virtual Plenary Poster Presentations: Osteoarthritis and Other Joint Disorders - Physicochemical properties and Regulation of IGF-1 Signaling in Osteophytes
Edward Hsiao, MD
Oral Presentations: Rare Bone Disease (Clinical) - Palovarotene for the Treatment of Fibrodysplasia Ossificans Progressiva in Females Aged >=8 Years and Males Aged >=10 Years: Data From the Phase III Move Trial
Clinical Oral Poster Session I - Palovarotene for the Treatment of Fibrodysplasia Ossificans Progressiva in Females Aged =8 Years and Males Aged =10 Years: Data From the Phase III Move Trial
Virtual Plenary Poster Presentations - Rare Bone Diseases: Clinical - Greater Heterotopic Ossification Burden Is Associated with Reduced Mobility, Function, and Quality of Life in Individuals with FOP
Virtual Plenary Poster Presentations - Rare Bone Diseases: Clinical - Efficacy of Palovarotene in Patients Who Transferred From a Fibrodysplasia Ossificans Progressiva Natural History Study to the Phase III MOVE Trial
Virtual Plenary Poster Presentations - Rare Bone Diseases: Clinical - A Global Natural History Study (NHS) of Fibrodysplasia Ossificans Progressiva (FOP): Normal Long Bone Growth and Abnormalities in Younger Patients over 36 Months
Holly Ingraham, PhD
Oral Presentations: Bone Interactions with other Tissues - A Brain Dependent Osteogenic Factor Controls Peak Bone Mass
Bone Interactions with Other Tissues - Interplay Between High Fat Diet and High Bone Mass In An Estrogen-Responsive Female Neuroskeletal Circuit
Serra Kaya, PhD
Oral Presentations: Osteocytes - Ablating osteocytic TGFβ signaling mitigates the effects of obesity on systemic energy balance and bone quality
Musculoskeletal Aging Poster - The Role of TGFβ-regulated Osteocytic Perilacunar/canalicular Remodeling in Age-related Bone Fragility
Galateia J. Kazakia, PhD
Biomechanics and Bone Quality Poster - Second-Generation HR-pQCT Accuracy and Cross-Calibration Study
Musculoskeletal Aging Poster - Effects of Age and Osteocyte Dysfunction on Bone Structural Changes During Hindlimb Unloading and Reloading in Mice
Virtual Plenary Poster Presentations: Osteoporosis - Secondary Osteoporosis - Spatial Homogeneity of Bone Marrow Adiposity is Increased in the Proximal Femur of People Living with HIV
Virtual Plenary Poster Presentations: Osteoporosis - Secondary Osteoporosis - Associations of Bone Marrow Adiposity with Trabecular Bone Mineral Density and Microarchitecture are Altered in the Proximal Femur of People Living with HIV
Tiffany Kim, MD
Osteoporosis - Nutrition, Dietary Supplements and Physical Activity Poster - Prebiotic Intervention to Improve Calcium Absorption in Postmenopausal Women After Gastric Bypass: A Randomized Controlled Trial
Eileen Koh, MD
Virtual Plenary Poster Presentations: Clinical Case Report - Localizing Parathyromatosis via 18F-Fluorocholine Positron Emission Tomography (PET) Neck Magnetic Resonance Imaging (MRI) in a Patient with an Activating GCM2 (glial cell missing 2) Mutation and Familial Isolated Hyperparathyroidism (HPT)
Roland Krug, PhD
Osteoporosis: Assessment Poster - MRI-based Vertebral Proton Density Fat Fraction Texture Analysis Predicts CT-based Bone Mineral Measurements
Virtual Plenary Poster Presentations: Osteoporosis - Secondary Osteoporosis - Spatial Homogeneity of Bone Marrow Adiposity is Increased in the Proximal Femur of People Living with HIV
Virtual Plenary Poster Presentations: Osteoporosis - Secondary Osteoporosis - Associations of Bone Marrow Adiposity with Trabecular Bone Mineral Density and Microarchitecture are Altered in the Proximal Femur of People Living with HIV
Janet Lee, MD
Bone Acquisition and Pediatric Bone Disorders Poster - Low areal bone mineral density in early pubertal transgender and gender diverse youth is associated with lower peripheral bone strength due to thinner cortices and lower trabecular density
Thomas Link, MD, PhD
Virtual Plenary Poster Presentations: Osteoporosis - Secondary Osteoporosis - Spatial Homogeneity of Bone Marrow Adiposity is Increased in the Proximal Femur of People Living with HIV
Virtual Plenary Poster Presentations: Osteoporosis - Secondary Osteoporosis - Associations of Bone Marrow Adiposity with Trabecular Bone Mineral Density and Microarchitecture are Altered in the Proximal Femur of People Living with HIV
Sharmila Majumdar, PhD
Symposium: A Look to the Future: Advances and Challenges in Clinical Bone Research - A Look to the Future: Advances and Challenges in Clinical Bone Research Artificial Intelligence and Imaging for an Integrated Approach to Musculoskeletal Aging
Ralph Marcucio, PhD
Oral Presentations: Bone Interactions with other Tissues - A Brain Dependent Osteogenic Factor Controls Peak Bone Mass
Kazu Morioka, PhD
Oral Presentations: Bone Interactions with other Tissues - A Brain Dependent Osteogenic Factor Controls Peak Bone Mass
Robert Nissenson, PhD
Virtual Plenary Poster Presentations - Bone Interactions with the Immune System - Progranulin Limits the Osteogenic Effect of Bone Marrow Macrophages
Virtual Plenary Poster Presentations - Preclinical Models of Musculoskeletal Disorders - Abaloparatide Directs the Fate of Osteoblast Progenitors during Fracture Repair
Stephen Rosenthal, MD
Bone Acquisition and Pediatric Bone Disorders Poster - Low areal bone mineral density in early pubertal transgender and gender diverse youth is associated with lower peripheral bone strength due to thinner cortices and lower trabecular density
Saghi Sadoughi, PhD
Biomechanics and Bone Quality Poster - Second-Generation HR-pQCT Accuracy and Cross-Calibration Study
Christian Santa Maria
Oral Presentations: Bone Interactions with other Tissues - Enhanced Skeletal Anabolism by Concurrently Targeting The Parathyroid Hormone 1 Receptor (PTH1R) and Extracellular Calcium-Sensing Receptor (CaSR)
Anne Schafer, MD
Education Advisory Committee, Co-Chairperson
Bone Acquisition and Pediatric Bone Disorders Poster - Low areal bone mineral density in early pubertal transgender and gender diverse youth is associated with lower peripheral bone strength due to thinner cortices and lower trabecular density
Osteoporosis - Nutrition, Dietary Supplements and Physical Activity Poster - Prebiotic Intervention to Improve Calcium Absorption in Postmenopausal Women After Gastric Bypass: A Randomized Controlled Trial
Charles Schurman
Musculoskeletal Aging Poster - The Role of TGFβ-regulated Osteocytic Perilacunar/canalicular Remodeling in Age-related Bone Fragility
Ann Schwartz, MD
Late-Breaking Oral Presentations: Clinical Treatment - Diabetes mellitus and the benefit of antiresorptive therapy on fracture risk: an FNIHASBMR SABRE study pooled analysis
Virtual Plenary Poster Presentations: Hormonal Regulators - Biochemical Markers of Bone Turnover in Older Adults with Type 1 Diabetes
Dolores Shoback, MD
2021 Program Advisory Committee
Diversity, Equity, and Inclusion Committee
Plenary session reviewing the most impactful clinical and basic science
Oral Presentations: Bone Interactions with other Tissues - Enhanced Skeletal Anabolism by Concurrently Targeting The Parathyroid Hormone 1 Receptor (PTH1R) and Extracellular Calcium-Sensing Receptor (CaSR)
Annual Review of Bone, Mineral and Musculoskeletal Research - Clinical Science Review
Late-Breaking Oral Presentation: Clinical Hyoparathyroidism and Hypeparathyroidism Guidelines - Guidelines on Diagnosis, Evaluation and Management of Hypoparathyroidism: 2021
Clinical Case Report Poster - Perplexing Case of Parathyroid Hormone (PTH) Resistance vs Hyposecretion: Pseudohypoparathyroidism Type 1B with Minimally Elevated PTH Levels
Virtual Plenary Poster Presentations: Clinical Case Report - Localizing Parathyromatosis via 18F-Fluorocholine Positron Emission Tomography (PET) Neck Magnetic Resonance Imaging (MRI) in a Patient with an Activating GCM2 (glial cell missing 2) Mutation and Familial Isolated Hyperparathyroidism (HPT)
Spenser Smith, PhD
Osteoblasts Poster - miR-433-3p Suppresses Bone Formation and mRNAs Critical for Osteoblast Function in Mice
Nico Sollmann, MD, PhD
Osteoporosis: Assessment Poster - MRI-based Vertebral Proton Density Fat Fraction Texture Analysis Predicts CT-based Bone Mineral Measurements
Liping Wang, MD, PhD
Oral Presentations: Bone Interactions with other Tissues - Abaloparatide Promotes Bone Formation At All Sites during Fracture Repair
Virtual Plenary Poster Presentations - Bone Interactions with the Immune System - Progranulin Limits the Osteogenic Effect of Bone Marrow Macrophages
Virtual Plenary Poster Presentations - Preclinical Models of Musculoskeletal Disorders - Abaloparatide Directs the Fate of Osteoblast Progenitors during Fracture Repair
Yongmei Wang, MD, PhD
Virtual Plenary Poster Presentations: Osteoarthritis and Other Joint Disorders - Physicochemical properties and Regulation of IGF-1 Signaling in Osteophytes
Kelly Wentworth, MD
ASBMR/ECTS Clinical Debate - For the Motion: Intermittent Drug Holidays are Mandatory for Long Term Bisphosphonate Treatment of Osteoporosis?
Industry Supported Symposium: Managing Fibrodysplasia Ossificans Progressiva (FOP): Therapeutic Advances
Karin Wu, MD
Osteoporosis - Nutrition, Dietary Supplements and Physical Activity Poster - Prebiotic Intervention to Improve Calcium Absorption in Postmenopausal Women After Gastric Bypass: A Randomized Controlled Trial
Po-Hung Wu, PhD
Biomechanics and Bone Quality Poster - Second-Generation HR-pQCT Accuracy and Cross-Calibration Study
Musculoskeletal Aging Poster - Effects of Age and Osteocyte Dysfunction on Bone Structural Changes During Hindlimb Unloading and Reloading in Mice
Virtual Plenary Poster Presentations: Osteoporosis - Secondary Osteoporosis - Spatial Homogeneity of Bone Marrow Adiposity is Increased in the Proximal Femur of People Living with HIV
Virtual Plenary Poster Presentations: Osteoporosis - Secondary Osteoporosis - Associations of Bone Marrow Adiposity with Trabecular Bone Mineral Density and Microarchitecture are Altered in the Proximal Femur of People Living with HIV
Cristal Yee, PhD
Oral Presentations: Osteocytes - Ablating osteocytic TGFβ signaling mitigates the effects of obesity on systemic energy balance and bone quality
Jihee Yoon
Oral Presentations: Osteocytes - Ablating osteocytic TGFβ signaling mitigates the effects of obesity on systemic energy balance and bone quality
Virtual Plenary Poster Presentations: Osteocytes - miR-181a/b coordinates osteocytic energy metabolism
CCMBM is proud to present this academic year's Seminar Series. We are delighted to bring this exciting line up of speakers to the UCSF community. Fall speakers will visit by Zoom, but we hope to welcome some Spring speakers in person.
CCMBM members, including junior investigators, have priority to meet with visiting faculty speakers. Take the poll to let the Seminar Committee know your meeting preferences. The Committee will follow up with scheduling details as we near each speaker’s visit.
Take the poll
Misung Han, PhD
Assistant Researcher
Department of Radiology and Biomedical Imaging
Project: Quantitative MRI to Evaluate Rotator Cuff Tendon Degeneration
Award: Pilot for Junior Investigators in Basic and Clinical/Translational Sciences/CTSI
Stefan Habelitz, PhD
Professor
Department of Preventive & Restorative Dental Sciences
Project: Innocuous tooth specimen sterilization using supercritical CO2
Award: Shared Technology Awards/ Academic Senate
Thank you to all the CCMBM members who completed this spring’s annual survey. Member feedback is critical to the center’s NIH P30 grant reporting requirements. We had a very good 61% response rate. This shows our membership's motivation and commitment to the center’s goals and enthusiasm towards its activities.
Young Investigator Growth in Relation to Overall CCMBM Membership by Year
CCMBM New Tools and Services
The UCSF’s Core Center for Musculoskeletal Biology and Medicine has some of the most advanced research imaging equipment in the world. Utilizing the CCMBM’s Skeletal Biology and Biomechanics Core protocol development, high resolution microCT, and their own breadth of research experience, Drs. Alan and Alexis Dang found themselves at an interesting conclusion - Could they use the evolutionary strengths of trabecular bone to help improve implant design? Their Tools & Technology grant that was awarded in 2018 allowed them to conduct their project, “3D Printing μCT Data,” and along with the SBB Core aided in the development of their 3D printing μCT data protocols.
Q #1: What is the lab to clinical need that was met with this invention?
A: The clinical challenge we have currently, is that bones don't always heal, either from a fracture, or surgical fusion or osteotomy procedure. Orthopaedic surgeons frequent employ internal implants to improve the rate of union, but the current implants are not optimized for their intended use. This invention utilizes the complex internal structure of our bones, that have been optimized for human gait through evolution, for medical implants. Often then lay understanding of trabecular bone is that it is a random, open cell foam, typical engineering simulations of bone-like structure, use a stochastic (random) pattern generation. Nothing could be further from reality, as the UCSF labs and teams have shown the purposeful structure of trabecular bone, consisting of a rod and plate construct.
Q #2: How were you able to move your lab idea to a patent?
A: Once we realized that we could quantify and translate the structure of the bone into a digital surface model that could be incorporated into implant design, we reached out to the UCSF Technology Transfer offices to discuss our idea. UCSF is of course, very well versed in innovation, and we quickly found a path to the patent and subsequent licensing.
Q #3: What advice do you have for other inventors?
A: I got this advice recently from another inventor. Write down everything you learn. Realize that much of what you may be doing is innovative and may be of value to others. Engage the UCSF Innovations team early. Sometimes your idea may not be ready yet, but sometimes it may be ready to patent. It is first to file that captures with IP. Additionally, the Office of Technology Management team at UCSF is very helpful as an ally. You don't need any prior knowledge of patent writing or the patent process. You simply focus on describing your invention, in detail to the team and they will put together a patent draft for review/editing.
During April 2021, the CCMBM along with UCSF Musculoskeletal Center, hosted a half-day symposium on Crosstalk in Osteoarthritis: Within and Beyond the Joint. The meeting convened 461 participants from 99 institutions and organizations across the US and Europe. The focus of the meeting was to recognize osteoarthritis as a disease that encompasses the whole joint as well as other systemic factors. The symposium featured keynote speakers Lindsey Criswell, MD, MPH, DSc (NIH NIAMS) and Judith Campisi, PhD (The Buck Institute for Research on Aging & Lawrence Berkeley National Laboratory, along with 17 invited speakers and panelists from three sessions that were supported by American Academy of Orthopaedic Surgeons, the Arthritis Foundation, and the Orthopaedic Research Society.
We invite you to check out the website where you can find recordings of all the sessions online. An interactive program with short speaker bios is included along with each session’s Q&A that was not captured during the webinar recording
The symposium was organized by Tamara Alliston, PhD (UCSF), Farshid Guilak, PhD (Shriners Hospitals for Children and Washington University), Jennifer Westendorf, PhD (Mayo Clinic), and Thomas Vail, MD (UCSF). Thank you to co-marketing partners Center for Skeletal Research (Harvard University), Center for Musculoskeletal Disorders (University of Pennsylvania) and the Orthopaedic Research Society.
At UCSF and the CCMBM, diversity has been a critical component of institutional success and we strive to foster equitable and inclusive environments that will lead to cutting edge discoveries, effective learning, and high-quality patient care.
As part of our commitment to diversity, equity and inclusion (DEI), CCMBM has formed a new partnership with The Benioff Center for Microbiome Medicine to co-sponsor the Antiracist Book Club series. Members of both Centers meet bi-monthly to discuss a text confronting racism and the experiences of being Black, Indigenous, and People of Color in America. The intention of these discussions is to provide us with the opportunity to learn, explore and become active participants in our community to valuing Black lives, dismantling systemic inequities, and embracing DEI.
Join us for the upcoming Antiracist Book Club on June 3rd. Discussion will be on the book “Are Prisons Obsolete?” by Angela Davis. CCMBM members are eligible for reimbursement of the book if purchased from a local or black-owned business.
Congratulations to CCMBM Members on their Awards
Congratulations the following CCMBM members on their awards!
PILOT/FEASIBILITY (FUNDER)
Victor Cheuy, PhD, Assistant Professor, Departments of Physical Therapy and Rehabilitation Science & Radiology and Biomedical Imaging, Electromechanical Dynamometer for Clinical Research of Skeletal Muscle Function (Academic Senate)
Valentina Pedoia, PhD, Assistant Professor, Department of Radiology & Biomedical Imaging, Multi-Task Deep Learning to Develop Automatic Scapular Shape Extraction from Clinical MR (CCMBM)
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CCMBM JUNIOR INVESTIGATOR RESEARCH GRANT
CCMBM launched the Junior Investigator Research Grant Program to support small independent research projects proposed by junior and early-stage investigators. Grants were awarded to:
Neha Dole, PhD, Assistant Researcher, Department Orthopaedic Surgery, Understanding the Role of Sirt1 in Obesity-induced Metabolic Dysfunction of Osteocytes
Karin Wu, MD, Research Fellow, Department of Medicine, VA Women's Health, The Role of Prebiotic-Induced Microbiome Alteration in Calcium Absorption and Bone Turnover After Gastric Bypass
Cheers to the New Year!
As we usher in 2021, we are excited to kick off a robust seminar series, begin new partnerships with other institutions and programs, and support our members and MSK community with their research.
We continuously seek to better understand how to serve you. As such, we are preparing the CCMBM annual member survey in preparation for our annual NIH NIAMS progress report. In advance, we thank you for your feedback. It is crucial for shaping future CCMBM services and programs that will benefit you and your research.
CCMBM Junior Investigator Research Grant
CCMBM launched the Junior Investigator Research Grant Program to develop junior and early-stage investigators’ independent research projects. Recipients of the grant were awarded to Neha Dole, PhD, who is an Orthopaedic Surgery Assistant Researcher studying “Understanding the Role of Sirt1 in Obesity-induced Metabolic Dysfunction of Osteocytes,” and Karin Wu, MD, who is an Endocrinology & Metabolism Clinical Research Fellow studying, “The Role of Prebiotic-Induced Microbiome Alteration in Calcium Absorption and Bone Turnover After Gastric Bypass.”
If you have an idea relating to an initiative the CCMBM could implement to enhance your career opportunities, please reach out to the CCMBM and/or join the Junior Investigator Committee, where your input is valued and can help shape our programs.
CCMBM 2021 Seminar Series
We are delighted to partner with Harvard University's Center for Skeletal Research and the various UCSF departments and programs to bring this year's CCMBM Seminar Series.
Contact Daniel Davis if you would like us to invite potential speakers for this coming summer and fall.
In Vivo MicroCT Imaging Moves to Parnassus Heights
The development of preclinical scanners has allowed us to perform microCT imaging on live, anesthetized animals. As a valuable strategy for longitudinal analysis of gross skeletal development and bone microarchitecture changes over a time period of weeks or months, this technology is used to identify skeletal changes in response to gene modification, pharmacological or biomechanical interventions, and musculoskeletal injury or cancer. Notable advantages of in vivo scanning are the reduction of animals needed for a study and can offer important information about transient or temporal physiological effects that are not observed at the endpoint.
This equipment will be online and ready for use on the Parnassus Campus later in Spring 2021; scans can be performed on mice inside LARC’s PSB barrier facility. Please contact Nick Szeto, SBB Core Manager, for more information.
CCMBM's First Virtual Retreat Convened Scientists from Multiple Institutions
This year the NIH P30 Core Center for Musculoskeletal Biology and Medicine (CCMBM) held its annual scientific retreat online. Co-sponsored with UCSF Department of Orthopaedic Surgery, Great Performances: Stretching the Limits of Musculoskeletal Biology and Medicine drew 133 attendees to join the 31 invited speakers and discussion leaders during September 22-23, 2020.
Inspired by elite performers who push the limits of what the musculoskeletal system can achieve, musculoskeletal research seeks to help everyone unleash their inner performer to live a healthy and active life. The retreat brought together researchers from 20 institutions to discuss cutting-edge research that aimed to transform human health by improving musculoskeletal function across the lifespan. Researchers from the biological, engineering, imaging, physical therapy, and epidemiologic sciences discussed advances in soft and mineralized skeletal tissues and muscle in health and disease.
We welcomed Dr. David Bradford Lectureship Keynote Speakers Terence Capellini, PhD, Richard B. Wolf Associate Professor of Human Evolutionary Biology from Harvard University, who spoke on “Exploring the Regulatory Control of Cartilage Development to Understand Skeletal Disease,” and Kate Law Hoflich, Professional Circus Artist, Artistic Director, and Coach, who shared a video performance and lecture on “Passion and Pain in the Performing Arts.” Ms. Hoflich also participated in a panel discussion with Anthony Luke, MD (UCSF Professor of Orhopaedic Surgery and primary care sports medicine doctor) and Stephanie Greenspan, PT, DPT (Samuel Merritt University Assistant Professor of Physical Therapy). The first day concluded with Keynote Speaker Rachael Callcut, MD, MSPH (UCSF Associate Professor of Surgery and Center for Digital Health Innovation), who spoke on “The Hype and Hope for AI in Medicine.”
The second day of the retreat featured sessions on Treatment & Restoration and Pathology & Pain, as well as a poster session. In each session, scientists discussed their efforts to find solutions to tackle musculoskeletal problems, from paraspinal muscle quality to osteoarthritis.
Congratulations to the Poster Winners!
Best Postdoc Poster - Serra Kaya, PhD, Transcriptomic Analysis of Aged Mouse Bone Identifies Novel Genes Enriched for Genetic Associations with Bone Fracture and Bone Mineral Density in Human
Second Place Postdoc Poster - Neha Dole, PhD, TGFβ Activates Wnt Signaling in Osteocytes: Regulation via miR-100
Best Graduate Student Poster (tie) - Alejandro Morales Martinez, Multimodal qMRI Framework for Knee Imaging Biomarker Fusion and Osteoarthritis Prediction
Best Graduate Student Poster (tie) - Charles Shurman, Degenerated Lacunar-Canalicular Networks and Osteocyte Mechanosensation in Bone with Aging and Disrupted TGFb Signaling
The CCMBM would like to thank event sponsors: UCSF Department of Orthopaedic Surgery, Dr. David Bradford Lectureship Fund, and Center for Disruptive Musculoskeletal Innovations (CDMI). Thank you to event partners: UCSF Dental School, UCSF Department of Physical Therapy and Rehabilitation Science, UCSF Department of Radiology and Biomedical Imaging, the Anti Aging Rejuvenation Initiative, and CCMBM Junior Investigator Committee. Kudos to the Scientific Retreat Committee: Galateia Kazakia, PhD, and Rich Schneider, PhD, Event Co-Chairs; Tamara Alliston, PhD; Daniel Davis, Neha Dole, PhD; Nicholas Hanne, PhD; Pui Yee Law; Jeffrey Lotz, PhD; and Spenser Smith, PhD.
Congratulations to CCMBM Members on their Awards
TOOLS AND TECHNOLOGY
Jinsook Suh, PhD, Postdoctural Researcher, Department of Orofacial Sciences, Elucidating the Epigenetic Regulation of p75NTR in Skeletal Development
Po-Hung Wu, PhD, Postdoctural Researcher, Department of Radiology & Biomedical Imaging, Cortical Bone Vasculature Imaging via Contrast-enhanced High-resolution Peripheral Quantitative Computed Tomography (HR-pQCT)
CCMBM/ORTHOPAEDIC SURGERY SCIENTIFIC RETREAT POSTER SESSION
Best Postdoc Poster - Serra Kaya, PhD (pictured left), Transcriptomic Analysis of Aged Mouse Bone Identifies Novel Genes Enriched for Genetic Associations with Bone Fracture and Bone Mineral Density in Human
Second Place Postdoc Poster - Neha Dole, PhD, TGFβ Activates Wnt Signaling in Osteocytes: Regulation via miR-100
Best Graduate Student Poster (tie) - Alejandro Morales Martinez, Multimodal qMRI Framework for Knee Imaging Biomarker Fusion and Osteoarthritis Prediction
Best Graduate Student Poster (tie) - Charles Shurman, Degenerated Lacunar-Canalicular Networks and Osteocyte Mechanosensation in Bone with Aging and Disrupted TGFb Signaling
Dr. Tamara Alliston Steps into Her New Role as CCMBM Center Director
For six years, Dr. Jeffrey Lotz was the CCMBM Center Director and decided it was time to hand the leadership role to someone new. Tamara Alliston, PhD was unanimously voted as Center Director due to her clear leadership experiences with the CCMBM and other university committees and her scientific achievements.
“After working with CCMBM in other capacities, I am ready for this new challenge – and am grateful to inherit this role from Dr. Jeffrey Lotz, who grew this vibrant program since its inception in 2014,” Dr. Alliston said.
Dr. Tamara Alliston is an exceptional scientist and leader who has served various leadership roles in the CCMBM and across UCSF. Dr. Alliston was initially SBB Core Co-Director, then quickly moved into the SBB Core Director role. She established and currently chairs the Junior Investigator Affairs Subcommittee and was the former Annual Scientific Retreat Chair. It was clear that she could easily step up to become the next CCMBM Director, a role that aligns with her leadership of the new UCSF Musculoskeletal Center. The CCMBM Leadership looks forward to working with her in the next 4 years of the second phase of the CCMBM.
We thank Dr. Lotz for his leadership these past six years and welcome Dr. Alliston as the new Center Director.
CCMBM 2020 Member Survey Results
Thank you to the CCMBM membership for taking the time this spring to complete our annual survey, which is critical to the CCMBM P30 reporting requirements for NIH. We had an overwhelming 73% response rate. This shows our membership's high motivation and commitment to the center’s goals and enthusiasm towards its activities. CCMBM and membership highlights are as follows:
Young Investigator Growth in Relation to Overall CCMBM Membership by Year
Interest in CCMBM New Services/Tools
UCSF CCMBM Earns Another 5 Years of P30 Funding
We are pleased to announce that we received a new P30 grant from NIH/NIAMS to support continuation of the Core Center for Musculoskeletal Biology and Medicine (CCMBM). Thank you to all the members who supported this successful grant submission by completing their annual survey. We received an overwhelming response, with a 91% survey completion rate. This significantly contributed to the proposal earning a perfect score for its administrative core, and a high impact score for the overall application (14).
The new P30 grant will enable the CCMBM to continue supporting the growing musculoskeletal research community across UCSF. Our goals for this next funding cycle are to build on past successes and to stimulate and support cross-campus collaborations and research efficiency that accelerate MSK science.
Please continue to help us improve our service by completing the CCMBM annual member survey as we are currently working on our first year’s progress report and final report close-out of the last 5 years. Please contact Daniel Davis if you need a new link to continue your survey. Or become a member to join the CCMBM community.
Bradford Lectureship Rescheduled
Dr. David S. Bradford is an internationally known orthopedic surgeon who treats patients with complex spinal disorders, including scoliosis, kyphosis, spondylolisthesis, and degenerative spine diseases. In addition to caring for patients, his research interests include biomaterials, tissue engineering, and tissue regeneration.
In April 2019, the Bradford Lectureship was established to honor those who have contributed significantly to MSK research. CCMBM’s inaugural distinguished lecturer was Corey Neu, PhD, Professor of Mechanical Engineering from the University of Colorado, who was featured at the UCSF CCMBM and Department of Orthopaedic Surgery Scientific Retreat - Unleashing your Inner Athlete: Accelerating MSK Healing through Discovery.
This year’s Bradford Lectureship features Lynda Bonewald, PhD. Dr. Bonewald is the Founding Director of the Indiana Center for Musculoskeletal Health, ICMH, a center with over 100 members from 36 departments and four campuses. She
has a primary faculty appointment in the Department of Anatomy, Cell Biology & Physiology and a secondary one in the Department of Orthopaedic Surgery. She is best known for her work in the study of osteocytes and is responsible for tools used by researchers globally to determine osteocyte biology and function. Although her lecture has been canceled due to COVID-19, we are working on rescheduling her visit when we resume normal activities per the policy and guidance of UCSF on non-essential events and gatherings for large groups.
Distinguished Faculty added to the CCMBM External Advisory Board
We are pleased to announce the appointment of Samuel R. Ward, PT, PhD as new member to the CCMBM External Advisory Board. Dr. Ward is Professor in the Departments of Orthopaedic Surgery, Radiology, and Bioengineering at UC San Diego. He is also Vice-Chair of Research in Orthopaedic Surgery, Co-Director of the Translational Science Partnerships Program, and Director of the Muscle Physiology Laboratory.
Dr. Ward is a clinician-scientist and his research program focuses on structure-function relationships in skeletal muscle, in normal and pathological conditions. His current focus is on understanding chronic muscle atrophy and cell death in mature adults, with an emphasis on the use of stem cells and regenerative medicine approaches to treat these disease processes.
Dr. Ward joins current External Advisory Board members Jane Cauley, DrPH, Professor of Epidemiology at University of Pittsburgh Graduate School of Public Health; Louis Soslowsky, PhD, Professor of Orthopaedic Surgery at the University of Pennsylvania; and Jennifer Westendorf, PhD, Professor of Orthopaedic Surgery at Mayo Clinic.
Unleashing Your Inner Athlete: Accelerating MSK Healing through Discovery
NIH P30 Core Center for Musculoskeletal Biology and Medicine (CCMBM) hosted a special two-day scientific retreat along with the Department of Orthopaedic Surgery at UCSF's Mission Bay campus during April 9-10, 2019.
We welcomed Paralympic Volleyball Gold Medalist Kari Miller, who gave an inspiring keynote on her life experiences as a U.S. Army veteran, double amputee, and competitive athlete. She also participated in a panel discussion with Julia Nichols, PhD (2012 Olympic Rowing), Richard O’Donnell, MD (Professor of Clinical Orthopaedic Surgery and Chief of the Orthopaedic Oncology Service), and Rich Souza, PhD, PT (Vice Chair for Research and Professor in the UCSF Department of Physical Therapy and Rehabilitation Science). The first day concluded with talks & posters by trainees, and a networking reception.
The second day of the retreat featured keynote lectures by Richard O’Donnell, MD; Todd McDevitt, PhD; and Corey Neu, PhD; along with 17 session speakers and discussion leaders, as well as a poster session. This year, the CCMBM is proud to include Corey Neu, PhD, Professor of Mechanical Engineering from the University of Colorado as the Inaugural Bradford Distinguished Lecturer. Over 140 participants attended, including CCMBM members, 23 UCSF departments represented in multiple schools, and ten institutions (UC San Francisco, UC Berkeley, UC Davis, and Stanford University, San Francisco VAMC, CPMC, Gladstone Institutes, University of Colorado, Redwood High School, and University of Melbourne) that brought musculoskeletal researchers, clinicians, and trainees.
In each session, scientists discussed their efforts to finding solutions to tackle musculoskeletal problems, from engineered stem-cells to systemic bone loss. Whether addressing these questions from a basic, translational, or clinical perspective, the CCMBM provided Core resources and pilot grant funding to support this work. In this way, the CCMBM aims to strengthen the resources and community of new and established investigators to improve musculoskeletal health.
Congratulations to the Slam Talk and Poster Winners!
- Best Slam Talk – Kei Katsura. Slam Talk Title: Teeth Come in Little Packages
- Best Postdoc Poster – Spenser Smith, PhD. Poster Title: The Role of TGFB Signaling in Neural Crest-Mediated Jaw Bone Remodeling
- Second Place Postdoc Poster – Benjamin Osipov, PhD. Poster Title: Determining the Effect of Osteocyte Dysfunction on Systemic Bone Loss after Fracture Using Bcl-2 Transgenic Mice
- Best Graduate Student Poster – Devante Horne. Poster Title: Development of a Custom LIPUS System and Demonstration of LIPUS-Induced Increase in Collagen Production in Intervertebral Disc Cells
- Second Place Grad Student Poster – Courtney Mazur. Poster Title: Osteocytic MMP13 Regulates Perilacunar/Canalicular Remodeling, Bone Quality, and Joint Disease
The CCMBM would like to thank event sponsors: UCSF Department of Orthopaedic Surgery, the Endocrine Unit at SF-VAMC, UCSF Dental School, UCSF Department of Physical Therapy and Rehabilitation Science, UCSF Department of Radiology and Biomedical Imaging, the Center for Disruptive Musculoskeletal Innovations (CDMI), and the Anti Aging Rejuvenation Initiative. A special acknowledgement to David S. Bradford, MD, Professor of Orthopedic Surgery, director of spine surgery and Chair Emeritus at UCSF, for establishing the Bradford Lectureship to honor those who have contributed significantly to MSK research. Kudos to the Scientific Retreat Committee: Tamara Alliston, PhD, and Galateia Kazakia, PhD, Event Co-Chairs; Jiun Chiun Chang, PhD; Roland Krug, PhD; Pui Yee Law; Jeffrey Lotz, PhD; and Richard Souza, PhD, PT.
Congratulations to the 2019 CCMBM Grantees
PILOT/FEASIBILITY (FUNDER)
Judith Ashouri, MD, Assistant Professor, Department of Medicine, In depth characterization of RA synovial T cells (Academic Senate)
Dennis Black, PhD, Professor, Department of Epidemiology & Biostatistics, Atypical Femur Fracture (AFF): Developing a predictive tool for AFF risk and establishing AFF impact on morbidity and mortality (CCMBM)
Andrew Brack, PhD, Associate Professor, Department of Orthopaedic Surgery, Antibody-directed inhibition of GDF11 to enhance aged skeletal muscle repair (Academic Senate)
Victor Cheuy, PhD, Assistant Professor, Department of Physical Therapy & Rehab Science, A Musculoskeletal and Biomechanical Analysis of Diabetic, Neuropathic Foot Deformity (CTSI)
Tejal Desai, PhD, Professor, Department of Bioengineering and Therapeutic Sciences, Local Delivery of Nerve Growth Factor via PEGDMA Microrods for Accelerated Bone Fracture Repair (Academic Senate)
Brian Feeley, MD, Professor, Department of Orthopaedic Surgery, Human Fibroadipoprogenitor (FAP) stem cells in rotator cuff disease: functional assessment of regenerative potential (REAC)
TRAVEL AWARD PROGRAM
Koren Roach, PhD - Osteoarthritis Research Society International (OARSI) World Congress on Osteoarthritis
Spenser Smith, PhD - International Association for Dental Research (IADR/AADR/CADR) General Session and Exhibition
Po-Hung Wu, PhD - International Society for Magnetic Resonance in Medicine (ISMRM 2019) Annual Meeting
CCMBM 2018 Member Survey Results
Thank you to all the CCMBM membership for taking the time to complete our survey, which was critical to the CCMBM P30 application requesting another 5-years of funding from NIH. We had an overwelming 91% response rate; our average response rate has been 30%. This shows the CCMBM member's motivation and commitment to its goals and enthusiasm to see the Center continue in the future. CCMBM and membership highlights are as follows:
CCMBM Membership
Summary of the Grants Supported from the CCMBM Community
CCMBM Activities Members Want Continued
Interest in CCMBM New Services/Tools
Congratulations to the 2018 CCMBM Grantees
PILOT/FEASIBILITY (FUNDER)
Doug Gould, PhD, Professor, Department of Ophthalmology, Mechanistic and Therapeutic Examination of Congenital Skeletal Defects in Col4a1 Mutant Mice (CCMBM and REAC)
Stephen Rosenthal, MD, Department of Medicine, Bone Density, Structure, and Estimated Strength in Transgender Youth Receiving Pubertal Suppression in Early Puberty (CTSI)
Liping Wang, MD, PhD, Assistant Professional Researcher, Department of Medicine, Role of Estrogen Receptor Alpha Signaling in Hypothalamus on Bone Metabolism during Lactation and Post Weaning Recovery (NCOEWH)
Rosanna Wustrack, MD, Assistant Professor, Department of Orthopaedic Surgery, Identifying and enhancing the host immune response in adult soft tissue sarcoma (CTSI)
TOOLS & TECHNOLOGY
Alan Dang, MD, Assistant Professor, Department of Orthopaedic Surgery, 3D printing μCT data
Musa Zaid, MD, Resident Physician, Department of Orthopaedic Surgery, Patient-Specific Pathologic Femur Fracture Risk Assessment using Geometrically Precise 3D-Printed Biomechanical Phantoms
CORE VOUCHER PROGRAM
Caitlin Chambers, MD, Sports Medicine Fellow, Department of Orthopaedic Surgery, Risk Factors For Progressive Degenerative Changes After Meniscal Root Tears As Defined By Longitudinal Magnetic Resonance Imaging
Daniel Clark, DDS, PhD, Postdoctoral Scholar, Department of Orofacial Sciences, Age-Related Changes of Macrophage: Implications for Immunomodulation in Periodontal Disease
Janet Lee, MD, MPH, Clinical Fellow, Department of Medicine, Bone density, structure, and estimated strength in transgender youth receiving pubertal suppression in early puberty
Beyond Boundaries: Translating Discoveries to Promote an Active and Healthy Lifestyle
The NIH P30 Core Center for Musculoskeletal Biology and Medicine (CCMBM) hosted a special two-day scientific retreat last month along with the Department of Orthopaedic Surgery at UCSF's Mission Bay campus during September 12-13, 2017. Special guest Scott Parazynski, MD, spoke about pushing limits in science and medicine as an astronaut, physician, pilot, inventor, and co-investigator on NASA/UCSF collaborative projects. In addition, the first day featured interactive exhibits, slam-style talks & posters by trainees, and a reception. The second day of the retreat featured keynote lectures by Judith Campisi, PhD; Holly Ingraham, PhD; and David Sassoon, PhD, along with concurrent sessions, and a poster session. Nearly 170 participants attended, including CCMBM members, and other UC San Francisco, UC Berkeley, and Stanford University musculoskeletal researchers, clinicians, and trainees.
In each session, scientists discussed their efforts to tackle musculoskeletal problems, from osteoporosis to rotator cuff injury. Whether addressing these questions from a basic, translational, or clinical perspective, the CCMBM provided Core resources and pilot grant funding to support this work. In this way, the CCMBM aims to strengthen the resources and community of new and established investigators to improve musculoskeletal health.
Congratulations to the Slam Talk and Poster winners!
- Best Slam Talk – Sarah Wong. Slam Talk Title: Where there's a Wnt there's a Way to Mend Broken Bones.
- Best Postdoc Poster – Katherine Wysham, PhD. Poster Title: Association of High Anti-Cyclic Citrullinated Peptide Seropositivity and Lean Mass Index with Low Bone Mineral Density in Rheumatoid Arthritis.
- Second Place Postdoc Poster – Annarita Scaramozza, PhD. Poster Title: Identification and characterization of a subset of satellite sells marked by Mx1-Cre.
- Best Graduate Student Poster – Courtney Mazur. Poster Title: TGF-beta signaling regulates bone quality through osteocyte perilacunar remodeling.
- Second Place Grad Student Poster – David Monteiro. Poster Title: A high-throughput hydrogel platform for studying tension-sensitive modulation of TGF-beta signaling.
The CCMBM would like to thank event sponsors: UCSF Department of Orthopaedic Surgery, Precision Medicine in Rheumatology (PREMIER), the Endocrine Unit at SF-VAMC, and the Center for Disruptive Musculoskeletal Innovations (CDMI). Kudos to Scientific Retreat committee: Tamara Alliston, PhD, Committee Chair; Wenhan Chang, PhD; Lindsey Criswell, MD, MPH; Alexis Dang, MD; Jeffrey Lotz, PhD; Mary Nakamura, MD; Cynthia Neben, PhD; Dolores Shoback, MD; Richard Souza, PhD, PT.
Members Leveraged Center's Funds
CCMBM members (from left) Andrew Burghardt, Galateia Kazakia, PhD, and Roland Krug, PhD recently used Center core's techniques to generate preliminary for their awarded research grants.
Three CCMBM members have used techniques that were developed and funded by the Center's cores to obtain R01 grants. Congratulations!
- Andrew Burghardt, Specialist, Department of Radiology, and Julio Carballido-
Gamio , PhD, (formerly at UCSF, now at the Department of Radiology at University of Colorado, Denver), Multi-PI R01 grant: Multi-Parametric Spatial Assessment of Bone with HR-pQCT - Galateia Kazakia, PhD, Assistant Professor, Department of Radiology, and Roland Krug, PhD (co-PI), Assistant Professor, Department of Radiology, Bone quality and marrow adiposity in subjects with HIV
Congratulations to CCMBM Pilot Grantees
We would like to congratulate the following CCMBM members for being awarded 2016-2017 Pilot grants:
- Wenhan Chang, PhD, Professor, Department of Medicine; and Farzana
Perwad , MD, Associate Professor, Department of Pediatrics, Central regulation of ion transport and skeletalmineralization by FGF23 and klotho (funded by CCMBM) - Brian Feeley, MD, Associate Professor, Department of Orthopaedic Surgery, Evaluation of satellite cell function and transplantation in rotator cuff injury (funded by CCMBM pending NIAMS approval)
- Holly Ingraham, PhD, Professor, Department of Cellular & Molecular Pharmacology, Dissecting a novel
sex dependent brain-bone axis in female mice (funded by National Center for Excellence in Women’s Health) - Sergey Magnitsky, PhD, Director of Small Animal MRI Facility, Department of Radiology, Preclinical MR imaging and spectroscopy of bacteria infection in spinal disc (funded by CCMBM)
- Liping Wang, Assistant Professional Researcher, Department of Medicine, Role of progranulin in skeletal
homeostasis (funded by REAC)
"The CCMBM Pilot/Feasibility grant award will help us tremendously to generate mouse models to test our hypothesis and gather preliminary data for an upcoming NIH-R01 grant application. Furthermore, our research project has benefited greatly from the intellectual support of exceptional skeletal biologists through forums
-- Farzana
New awardee recruited into the skeletal biology field
Congratulations to Doug Gould, PhD, for obtaining a CCMBM Pilot/Feasibility grant for established investigators for his research: Characterizing skeletal defects in Col4a1 mutant mice.
“Simply put, without the CCMBM, we would not be doing skeletal research,” Dr. Gould, an Associate Professor in the Department of Ophthalmology, said. “We had observations that were nearly six years-old when I saw
“We dusted off the data for a consultation with Dr. Wenhan Chang and Alfred Li, and before we knew, we had a full-fledged skeletal biology project. Without these resources, and their kindness and expertise, none of this would have happened,” Dr. Gould added. (Dr. Chang is the Co-Director of the core; Li is the Core’s Manager). “Even now that the project is running, we continue to consult with the team, including Dr. Alliston, regularly. It has been a fun and productive 'team science' approach.” For more information about our other grantees, please visit our Research section.
