September 2017 Update

Beyond Boundaries: Translating Discoveries to Promote an Active and Healthy Lifestyle

The NIH P30 Core Center for Musculoskeletal Biology and Medicine (CCMBM) hosted a special two-day scientific retreat last month along with the Department of Orthopaedic Surgery at UCSF's Mission Bay campus during September 12-13, 2017. Special guest Scott Parazynski, MD, spoke about pushing limits in science and medicine as an astronaut, physician, pilot, inventor, and co-investigator on NASA/UCSF collaborative projects. In addition, the first day featured interactive exhibits, slam-style talks & posters by trainees, and a reception. The second day of the retreat featured keynote lectures by Judith Campisi, PhDHolly Ingraham, PhD; and David Sassoon, PhD, along with concurrent sessions, and a poster session. Nearly 170 participants attended, including CCMBM members, and other UC San Francisco, UC Berkeley, and Stanford University musculoskeletal researchers, clinicians, and trainees.

L-R: Jeffrey Lotz, PhD, CCMBM Director; Tamara Alliston, PhD, Scientific Retreat Chair; Scott Parazynski, MD, keynote speaker. Photo by Tue Nam Ton.

​In each session, scientists discussed their efforts to tackle musculoskeletal problems, from osteoporosis to rotator cuff injury.  Whether addressing these questions from a basic, translational, or clinical perspective, the CCMBM provided Core resources and pilot grant funding to support this work.  In this way, the CCMBM aims to strengthen the resources and community of new and established investigators to improve musculoskeletal health.

    Congratulations to the Slam Talk and Poster winners!
    Sarah Wong gives slam talk to event attendees. Photo by Tue Nam Ton.
    • Best Slam Talk – Sarah Wong. Slam Talk Title: Where there's a Wnt there's a Way to Mend Broken Bones.
    • Best Postdoc Poster – Katherine Wysham, PhD. Poster Title: Association of High Anti-Cyclic Citrullinated Peptide Seropositivity and Lean Mass Index with Low Bone Mineral Density in Rheumatoid Arthritis.
    • Second Place Postdoc Poster – Annarita Scaramozza, PhD. Poster Title: Identification and characterization of a subset of satellite sells marked by Mx1-Cre.
    • Best Graduate Student Poster – Courtney Mazur. Poster Title: TGF-beta signaling regulates bone quality through osteocyte perilacunar remodeling. 
    • Second Place Grad Student Poster – David Monteiro. Poster Title: A high-throughput hydrogel platform for studying tension-sensitive modulation of TGF-beta signaling.     

    The CCMBM would like to thank event sponsors: UCSF Department of Orthopaedic Surgery, Precision Medicine in Rheumatology (PREMIER), the Endocrine Unit at SF-VAMC, and the Center for Disruptive Musculoskeletal Innovations (CDMI). Kudos to Scientific Retreat committee: Tamara Alliston, PhD, Committee Chair; Wenhan Chang, PhD; Lindsey Criswell, MD, MPH; Alexis Dang, MD; Jeffrey Lotz, PhD; Mary Nakamura, MD; Cynthia Neben, PhD; Dolores Shoback, MD; Richard Souza, PhD, PT.



    February 2017 Update

    Members Leveraged Center's Funds

    CCMBM members (from left) Andrew Burghardt, Galateia Kazakia, PhD, and Roland Krug, PhD recently used Center core's techniques to generate preliminary for their awarded research grants.

    Three CCMBM members have used techniques that were developed and funded by the Center's cores to obtain R01 grants. Congratulations!

    • Andrew Burghardt, Specialist, Department of Radiology, and Julio Carballido-Gamio, PhD, (formerly at UCSF, now at the Department of Radiology at University of Colorado, Denver), Multi-PI R01 grant: Multi-Parametric Spatial Assessment of Bone with HR-pQCT
    • Galateia Kazakia, PhD, Assistant Professor, Department of Radiology, and Roland Krug, PhD (co-PI), Assistant Professor, Department of Radiology, Bone quality and marrow adiposity in subjects with HIV

    2016-17 Pilot Grantees

    We would like to congratulate the following CCMBM members for being awarded Pilot grants:

    • Wenhan Chang, PhD, Professor, Department of Medicine; and Farzana Perwad, MD, Associate Professor, Department of Pediatrics, Central regulation of ion transport and skeletal mineralization by FGF23 and klotho (funded by CCMBM)
    • Brian Feeley, MD, Associate Professor, Department of Orthopaedic Surgery, Evaluation of satellite cell function and transplantation in rotator cuff injury (funded by CCMBM pending NIAMS approval)
    • Holly Ingraham, PhD, Professor, Department of Cellular & Molecular Pharmacology, Dissecting a novel sex dependent brain-bone axis in female mice (funded by National Center for Excellence in Women’s Health)
    • Sergey Magnitsky, PhD, Director of Small Animal MRI Facility, Department of Radiology, Preclinical MR imaging and spectroscopy of bacteria infection in spinal disc (funded by CCMBM)
    • Liping Wang, Assistant Professional Researcher, Department of Medicine, Role of progranulin in skeletal homeostasis (funded by REAC)

    Dr. Brian Feeley recently received a CCMBM Pilot/Feasibility grant to perform research on a common shoulder problem.  He has collaborated with Xuhui Liu, MD (CCMBM member), Hubert Kim, MD, and other researchers at UCSF on developing models to study the molecular mechanisms and cellular mechanisms that are responsible for the development of muscle atrophy after rotator cuff tears. Image: Arrow indicating human satellite cells



    "The CCMBM Pilot/Feasibility grant award will help us tremendously to generate mouse models to test our hypothesis and gather preliminary data for an upcoming NIH-R01 grant application. Furthermore, our research project has benefited greatly from the intellectual support of exceptional skeletal biologists through forums organized by the CCMBM and the technical support of the state-of-the-art CCMBM Cores funded by the Center. With this support, we are confident that our innovative proposal will significantly move the research field forward in finding new strategies to treat skeletal disorders caused by inherited and acquired conditions of FGF23/klotho excess and deficiency in children and adults.” 

    -- Farzana Perwad, MD, Associate Professor, Department of Pediatrics (co-Investigator), who is working in partnership with Wenhan Chang, PhD, Professor, Department of Medicine


    March 2016 Update

    New awardee recruited into the skeletal biology field


    Congratulations to Doug Gould, PhD, for obtaining a CCMBM Pilot/Feasibility grant for established investigators for his research: Characterizing skeletal defects in Col4a1 mutant mice. “Simply put, without the CCMBM, we would not be doing skeletal research,” Dr. Gould, an Associate Professor in the Department of Ophthalmology, said. “We had observations that were nearly six years-old when I saw Dr. Tamara Alliston talk about the Skeletal Biology and Biomechanics Core at an afternoon workshop on campus.” (Dr. Alliston is the Director of the CCMBM Skeletal Biology and Biomechanics Core.)

    “We dusted off the data for a consultation with Dr. Wenhan Chang and Alfred Li, and before we knew, we had a full-fledged skeletal biology project. Without these resources, and their kindness and expertise, none of this would have happened,” Dr. Gould added. (Dr. Chang is the Co-Director of the core; Li is the Core’s Manager). “Even now that the project is running, we continue to consult with the team, including Dr. Alliston, regularly. It has been a fun and productive 'team science' approach.”  For more information about our other grantees, please visit our Research section.