Large clinical studies funded by NIAMS, other NIH institutes, and non-NIH funders have been instrumental in the building of our knowledge about osteoporosis and osteoarthritis (OA), and in the development of clinical guidelines for their diagnosis and treatment. Over the last 30 years, UCSF has served as the coordinating center for many of these studies. For example, the Study of Osteoporotic Fractures (SOF) and Osteoporosis in Men (MrOS) study, NIAMS-NIA co-funded projects, have been the source of much of our understanding of the relationship of bone mineral density (BMD) and other risk factors to fracture. SOF began following 9704 women in 1986 and MrOS 5994 men in 2000. UCSF coordinates the world’s two largest and longest running cohort studies of knee and hip OA, the OA Initiative (OAI) and the Multicenter OA Study (MOST), which together have enrolled, and followed up to 14 years, 7,800 racially diverse subjects. In conducting these studies, which have generated >1000 papers, we built and analyzed very large databases of clinical characteristics, biological archives (serum, whole blood, DNA), and radiologic images.
These are available to CCMBM members, along with data/resources from other observational and randomized trial cohorts following >60,000 people with >500,000 person-years of follow-up.
EB Core_research databases pdf
If you would like to learn more about using these clinical study databases, please review this list of studies and contact program coordinator Lucy Wu at [email protected] or 415-514-8157
