Seminar & Workshop Recordings

This workshop discusses challenges, strategies, and opportunities related to translating basic science discoveries into clinical practice and commercial success. Experts on basic science, clinical medicine, and entrepreneurship discuss:

• how to incorporate translational considerations into study aims
• types of evidence needed to change clinical management
• how discoveries are commercialized

Workshop Speakers:

Dennis Black, PhD
Professor, Department of Epidemiology & Biostatistics

Alexis Dang, MD
Professor, Department of Orthopaedic Surgery

Charles Hart, PhD
Executive Director, UCSF Catalyst Program

Sarah Knox, PhD
Professor, Department of Cell & Tissue Biology

Conor O’Neill, MD
Professor, Department of Orthopaedic Surgery

Recorded on March 27, 2024.

This workshop--presented by CCMBM EBSD Core co-director Dan Evans, PhD, MPH--covers many of the steps needed to perform a genome-wide association study (GWAS), with a focus on musculoskeletal (MSK) traits and outcomes. The workshop slides can be downloaded here.

Discussion points:

• GWAS study design
• What can be a learned from a GWAS
• Regulatory and compliance steps needed to gain access to genome-wide genotype data
• Common file types used for genome-wide genotype data
• Quality control (QC) approaches
• Association testing methods and result interpretation

Recorded on February 15, 2024.

Watch the Orthopaedic Surgery Research Seminar featuring Fiona Freeman, PhD, Assistant Professor and Ad Astra Fellow, University College Dublin, and Stefaan Verbruggen, PhD, FHEA, Lecturer & Visiting Academic, Queen Mary University of London & Insigneo Institute for in silico Medicine.

Dr. Freeman gave a presentation entitled, "Utilizing Bioengineering Technologies to Create Innovative Therapeutics for the Repair of Damaged or Diseased Bone."

Dr. Verbruggen gave a presentation entitled, "Osteocyte-cancer cell crosstalk in the bone metastatic niche."

Recorded on January 31, 2024.

This workshop--presented at UCSF on January 17, 2024--provides an overview of clinical biomechanics best practices featuring experts from the UCSF Human Performance Center including:

Anthony Luke, MD, MPH
Director, UCSF Human Performance Center

Richard Souza, PT, PhD
Director of Research, UCSF Human Performance Center

Brooke Schultz, MS, ACE-CPT
Biomechanist & Lab Manager, UCSF Human Performance Center

Mathias Sorensen, MS, ACE-CPT
Exercise Physiologist, UCSF Human Performance Center

The workshop included demos of the technology in the UCSF Human Performance Center (top video) followed by a separate lecture portion (bottom video). To view the workshop's data outputs, click here.
 

Watch the CCMBM seminar featuring Elena Ambrogini, MD, PhD, Assistant Professor of Medicine, Division of Endocrinology & Metabolism, University of Arkansas for Medical Sciences.

Dr. Ambrogini gave a presentation entitled, “Role of oxidized phospholipids in bone metabolism".

Recorded on January 9, 2024. Due to some technical issues, a portion of Dr. Ambrogini's talk is missing from this recording.

This workshop--recorded on August 30, 2023--provides a high-level overview of skeletal proteomics best practices featuring experts from the Buck Institute and the Medical University of South Carolina including:

Peggi Angel, PhD
Associate Professor of Cell & Molecular Pharmacology & Experimental Therapeutics at Medical University of South Carolina

Birgit Schilling, PhD
Director of the Mass Spectrometry Core & Professor at Buck Institute for Research on Aging

Charlie Schurman, PhD
Postdoctoral Research Fellow, Schilling Lab at Buck Institute for Research on Aging

Jacob Rose, MS
Project Scientist, Schilling Lab at Buck Institute for Research on Aging

Per his request, a portion of Dr. Schurman's presentation has been redacted from this recording.

Join Dr. Ralph Marcucio, a reviewer for the NIH Skeletal Biology Structure and Regeneration study section, for an overview of biosketch writing best practices. Dr. Marcucio will also show you how to tailor your biosketch to strengthen a grant application.

This workshop was recorded on April 20, 2023.

The resources shared by Dr. Marcucio during his presentation are as follows: 

Current instructions for biosketches from the NIH
Biosketch forms, and examples from the NIH
Create your own biosketch online via SciENv
Biosketch FAQ from the NIH
"How to write an NIH Biosketch" on YouTube

Watch the CCMBM & Department of Orthopaedic Surgery sponsored seminar featuring Jeffrey N. Katz, MD, Professor of Medicine and Orthopaedic Surgery at Harvard Medical School.

Dr. Katz gave a presentation entitled, “Management of Meniscal Tear in Middle-Aged and Older Adults”.

Recorded on December 13, 2022.

Watch the CCMBM Seminar Series featuring Fabrisia Ambrosio, PhD, MPT, Inaugural Director of the Atlantic Charter Discovery Center for Musculoskeletal Recovery at the Spaulding Research Institute, Harvard Medical School.

Dr. Ambrosio gave a presentation entitled, "Forever Young: Targeting Youthful Signals in Circulating Extracellular Vesicles through Engineering and Exercise."

Recorded November 30, 2022.

Watch the CCMBM Seminar Series featuring Warren Grayson, PhD, Professor and Vice-Chair for Faculty Affairs in the Department of Biomedical Engineering at Johns Hopkins University.

Dr. Grayson gave a presentation entitled, "Decoding Neurovascular Interactions to Promote Musculoskeletal Regeneration."

Recorded on October 26, 2022.

Watch the CCMBM Seminar Series featuring Isidro B. Salusky, MD, Distinguished Professor of Pediatrics at the David Geffen School of Medicine at UCLA, Chief of Pediatric Nephrology and Director of the Pediatric Dialysis Program.

Dr. Salusky gave a presentation entitled, "Is there a Clinical Role for the Performance of Bone Biopsy in Renal Osteodystrophy?"

Recorded on September 28, 2022.

Watch the CCMBM Seminar Series featuring Gabriel Mbalaviele, PhD, Professor of Medicine, Washington University in St. Louis.

Dr. Mbalaviele gave a presentation "Parsing the Paradoxical Pyroptotic and Osteoclastogenic Fates of Macrophages."

Recorded on April 21, 2022.

​​​​​Watch the CCMBM Seminar Series featuring Mishaela Rubin, MD, Associate Professor of Medicine, Columbia University.

Dr. Rubin gave a presentation on Hypoparathyroidism in 2022.

Recorded on February 10, 2022.

​​​​​Watch the CCMBM Seminar Series featuring Michelle McDonald, PhD, Bone Microenvironment Group Leader of the Bone Microenvironment Group at the Garvan Institute of Medical Research in Sydney, Australia.

Dr. McDonlad gave a presentation on Osteomorps and Osteoclast Recycling: A Mechanism for Rebound Bone Loss Following Withdrawal of Denosumab Therapy.

Recorded on December 2, 2021.

Watch the CCMBM Advanced Machine Learning Workshop focused on implementing and training an image classifier model to classify Covid-19 x-rays. The workshop showcased how to load and visualize data, balance and split your dataset, and train a model using the PyTorch framework. 

Recorded October 20, 2021.

Listen in for this CCMBM sponsored seminar provided by Brent Richards, MD, MSc, Professor of Medicine, Human Genetics and Epidemiology, and Biostatistics, McGill University, Quebec

Dr. Richards spoke on the topic of Genetics to Identify Drug Targets for Osteoporosis.

Recorded on September 24, 2021.
 

Listen in to this CCMBM sponsored seminar featuring Nicholas Harvey, MA, MB, BChir, PhD, FRCP, Professor of Rheumatology and Clinical Epidemiology, University of South Hampton, UK.

Dr. Harvey spoke on "The role of muscle measures in fracture risk assessment: findings from MrOS and WHI."

Recorded on July 8, 2021.
 

                                                             *Note: Some of the data in this presentation is unpublished, so certain slides are blurred.

Listen in to our March CCMBM Seminar series featuring Marc Wein, MD, PhD, Professor of Medicine, Harvard University. He provided provided a talk entitled “Dissecting novel mechanisms of osteocyte differentiation and function.” 

Tune into this CCMBM Seminar featuring Tony Keaveny, PhD, Professor of Mechanical Engineering & Bioengineering at UC Berkeley. He gave a talk a talk entitled “Biomechanical Computed Tomography Analysis (BCT) and its Clinical Use for Assessing Osteoporosis”

Listen in to us part two of a two-day Bradford Lectureship featuring Lynda Bonewald, PhD, Director of the Indiana Musculoskeletal Center & Professor of Anatomy, Cell Biology, Physiology and Orthopaedic Surgery at Indiana University. Talk title: “The Generation of Tools to Study Osteocytes: Cell lines and Cre models”

*Note: Some of the data in this presentation is unpublished, so certain slides are blurred.

Listen in to part one of a two-day lecture featuring Bradford Lectureship speaker Lynda Bonewald, PhD, Director of the Indiana Musculoskeletal Center & Professor of Anatomy, Cell Biology, Physiology and Orthopaedic Surgery at Indiana University. Talk title: “Beyond Movers and Shakers: Bone and Muscle as the Musculoskeletal Endocrine Unit”

Listen in to the CCMBM Seminar Series that was recorded on on December 16th, 2020 - featuring Julio Carballido-Gamio, PhD, Assistant Professor of Radiology at the University of Colorado Denver- Anschutz Medical Center. His talk was entitled “A Decade of Statistical Parametric Mapping in Bone Studies: What Have We Learned?”

This demo workshop showcases innovative tools that support musculoskeletal discovery using published genome-wide association study results. These tools aim to support laboratory researchers, even those with minimal computational experience, in leveraging large genome-wide association studies to prioritize clinically relevant genes for further laboratory study.Click the link above to view. 

The CCMBM/PREMIER MSK Genomics Workshop that took place on November 12, 2020 was entitled “New Computational Tools for Musculoskeletal Discovery using Genome-wide Approaches.”​​​​​​