Publications

Building a Better Bone: Promoting Endochondral Ossification to Stimulate Vascularized Bone Regeneration

Characterizing Skeletal Defects in Col4a1 mutant mice

  • Mazur C, Labelle-Dumais C, Acevedo C, Alliston T, and Gould D. 2016. Tackling Joint Disease by Understanding Crosstalk between Cartilage and Bone Research. AAOS/ORS Symposium: Rosemont, IL, 2016.

Endplate dysfunction in disc degeneration: Investigating solute transport kinetics, disc cell viability, and new imaging methods

Neuro-regulation of osteoporosis and heterotopic ossification after spinal cord injury

Publications supported by CCMBM

  • Acevedo C, Sylvia M, Schaible E, Graham JL, Stanhope KL, Metz LN, Gludovatz B, Schwartz AV, Ritchie RO, Alliston TN, Havel PJ, Fields AJ. Contributions of material properties and structure to increased bone fragility for a given bone mass in the UCD-T2DM rat model of type 2 diabetes. J Bone Miner Res. 2018 Jan. doi: 10.1002/jbmr.3393. [Epub ahead of print] PMID: 29342321.
  • Abbott MJ, Roth TM, Ho L, Wang L, O'Carroll D, Nissenson RA. Negative skeletal effects of locally produced adiponectin. PLoS One. 2015 Jul; 10(7):e0134290. PMID: 26230337; PMCID: PMC4521914.
  • Akil O, Hall-Glenn,F, Chang J, Li A, Chang W, Lustig LR, Alliston T, and Hsiao EC (2014). Disrupted bone remodeling leads to cochlear overgrowth and hearing loss in a mouse model of fibrous dysplasia. PLoSOne. 2014 May;9(5):e94989. PMCID: PMC4006800.
  • Alba D, Farooq JA, Lin MYC, Schafer AL, Shepherd J, Koliwad SK. Subcutaneous fat fibrosis links obesity to reduced glycemic control in Chinese Americans. J Clin Endocrinol Metab. 2018 May. doi: 10.1210/jc.2017-02301. [Epub ahead of print] PMID: 29846621.
  • Al-Dujaili SA, Koh AJ, Dang M, Mi X, Chang W, Ma PX, McCauley LK. Calcium sensing receptor function supports osteoblast survival and acts as a co-factor in PTH anabolic actions in bone. J Cell Biochem. 2016 Jul;117(7):1556-67. PMID: 26579618.
  • Almubarak S, Nethercott H, Freeberg M, Beaudon C, Jha A, Jackson W, Marcucio R, Miclau T, Healy K, Bahney C. Tissue engineering strategies for promoting vascularized bone regeneration. Bone. 2016 Feb;83:197-209. doi: 10.1016/j.bone.2015.11.011. Epub 2015 Nov 19. Review. PubMed PMID: 26608518; PubMed Central PMCID: PMC4911893.
  • Babey M, Wang Y, Kubota T, Fong C, Menendez A, ElAlieh HZ, Bikle DD. Gender-specific differences in the skeletal response to continuous PTH in mice lacking the IGF1 receptor in mature osteoblasts. J Bone Miner Res. 2015 Jun;30(6):1064-76. doi: 10.1002/jbmr.2433. PMID: 25502173.
  • Bahney CS, Hu DP, Miclau T 3rd, Marcucio RS. The multifaceted role of the vasculature in endochondral fracture repair. Front Endocrinol (Lausanne). 2015 Feb;6:4. eCollection 2015. Review. PMID: 25699016; PMCID: PMC4318416.
  • Bell KJ, Hayen A, Glasziou P, Irwig L, Eastell R, Harrison SL, Black DM, Bauer DC. Potential Usefulness of BMD and bone turnover monitoring of zoledronic acid therapy among women with osteoporosis: secondary analysis of randomized controlled trial data. J Bone Miner Res. 2016 Sep;31(9):1767-73. doi: 10.1002/jbmr.2847. Epub 2016 Apr. PMID: 27027655.
  • Berg-Johansen B, Fields AJ, Liebenberg EC, Li A, Lotz JC. Structure-function relationships at the human spinal disc-vertebra interface. J Orthop Res. 2018 Jan;36(1):192-201. doi: 10.1002/jor.23627. Epub 2017 Jun. PMID: 28590060; PMCID: PMC5720932.
  • Berg-Johansen B, Han M, Fields AJ, Liebenberg EC, Lim BJ, Larson PE, Gunduz-Demir C, Kazakia GJ, Krug R, Lotz JC. Cartilage Endplate Thickness Variation Measured by Ultrashort Echo-Time MRI is associated with adjacent disc degeneration. Spine (Phila Pa 1976). 2018 May 15;43(10):E592-E600. doi: 10.1097/BRS.0000000000002432. PubMed PMID: 28984733; PubMed Central PMCID:PMC5882595.
  • Berg-Johansen B, Jain D, Liebenberg EC, Fields AJ, Link TM, O'Neill CW, Lotz JC. Tidemark avulsions are a predominant form of endplate irregularity. Spine (Phila Pa 1976). 2018 Jan. PMID: 29315127.
  • Berg-Johansen B, Liebenberg EC, Li A, Macias BR, Hargens AR, Lotz JC. Spaceflight-induced bone loss alters failure mode and reduces bending strength in murine spinal segments. J Orthop Res. 2016 Jan;34(1):48-57. doi:10.1002/jor.23029. Epub 2015 Aug. PMID: 26285046; PMCID:PMC5477841.
  • Bertholet AM, Kazak L, Chouchani ET, Bogaczyńska MG, Paranjpe I, Wainwright GL, Bétourné A, Kajimura S, Spiegelman BM, Kirichok Y. Mitochondrial patch clamp of beige adipocytes reveals UCP1-positive and UCP1-negative cells both exhibiting futile creatine cycling. Cell Metab. 2017 Apr;25(4):811-822.e4. doi:10.1016/j.cmet.2017.03.002. PMID: 28380374; PMCID:PMC5448977.
  • Bikle DD, Tahimic C, Chang W, Wang Y, Philippou A, Barton ER. Role of IGF-I signaling in muscle bone interactions. Bone. 2015 Nov;80:79-88. doi: 10.1016/j.bone.2015.04.036. Review. PMID: 26453498; PMCID: PMC4600536.
  • Bucknor MD, Rieke V, Seo Y, Horvai AE, Hawkins RA, Majumdar S, Link TM, Saeed M. Bone remodeling after MR imaging-guided high-intensity focused ultrasound ablation: evaluation with MR imaging, CT, Na(18)F-PET, and histopathologic examination in a swine model. Radiology. 2015 Feb; 274(2):387-94. PMID: 25302829; PMCID: PMC4314293.
  • Cain CJ, Gaborit N , Lwin W, Barruet E, Ho S, Bonnard C, Hamamy H, Shboul, M, Reversade, B, Kayserili H, Bruneau BG, and Hsiao EC. (2016). Loss of Iroquois homeobox transcription factors 3 and 5 in osteoblasts disrupts cranial mineralization. Bone Rep. 2016 Dec;5:86-95. PMID: 26901092.
  • Carballido-Gamio J, Bonaretti S, Saeed I, et al. Automatic multi-parametric quantification of the proximal femur with quantitative computed tomography. Quant Imaging Med Surg. 2015;5(4):552-68.
  • Carballido-Gamio J, Bonaretti S, Kazakia G, Khosla S, Majumdar S, Lang TF, Burghardt AJ. Statistical parametric mapping of HR-pQCT Images: A Tool for population-based local comparisons of micro-scale bone features. Ann Biomed Eng. 2017 Apr; 45(4):949-962. PMID: 27830488.
  • Carriero A, Zimmermann EA, Paluszny A, Tang SY, Bale H, Busse B, Alliston T, Kazakia G, Ritchie RO, Shefelbine SJ. How tough is brittle bone? Investigating osteogenesis imperfecta in mouse bone. J Bone Miner Res. 2014 Jun;29(6):1392-401. PMID: 24420672.
  • Chanchek N, Gersing AS, Schwaiger BJ, Nevitt MC, Neumann J, Joseph GB, Lane NE, Zarnowski J, Hofmann FC, Heilmeier U, McCulloch CE, Link TM. Association of diabetes mellitus and biochemical knee cartilage composition assessed by T(2)relaxation time measurements: Data from the osteoarthritis initiative. J Magn Reson Imaging. 2018 Feb;47(2):380-390. doi: 10.1002/jmri.25766. Epub 2017 May 26.PubMed PMID: 28556419; PubMed Central PMCID: PMC5702599.
  • Chiang JM, Kaysen GA, Schafer AL, Delgado C, Johansen KL. Fibroblast growth factor 23 is associated with adiposity in patients receiving hemodialysis: possible cross talk between bone and adipose tissue. J Ren Nutr. 2018 Mar. [Epub ahead of print] PMID: 29606304.
  • Davies MR, Garcia S, Tamaki S, Liu X, Lee S, Jose A, Pomerantz JH, Feeley BT. Muscle stem cell activation in a mouse model of rotator cuff injury. J Orthop Res. 2017 Aug. doi: 10.1002/jor.23679. PMID: 28786534.
  • Degmetich S, Bailey JF, Liebenberg E, Lotz JC. Neural innervation patterns in the sacral vertebral body. Eur Spine J. 2016 Jun;25(6):1932-8. doi: 10.1007/s00586-015-4037-4. Epub 2015 Jun 16. PubMed PMID: 26077098; PubMed Central PMCID: PMC4681698.
  • Dole NS, Mazur CM, Acevedo C, Lopez JP, Monteiro DA, Fowler TW, Gludovatz B, Walsh F, Regan JN, Messina S, Evans DS, Lang TF, Zhang B, Ritchie RO, Mohammad KS, Alliston T. Osteocyte-intrinsic TGF-beta signaling regulates bone quality through perilacunar/canalicular remodeling. Cell Rep. 2017 Nov;21(9):2585-2596. PMID: 29186693.
  • Dudli S, Fields AJ, Samartzis D, Karppinen J, Lotz JC. Pathobiology of modic changes. Eur Spine J. 2016 Nov;25(11):3723-3734. Epub 2016 Feb 25. Review. PubMed PMID: 26914098; PubMed Central PMCID: PMC5477843.
  • Dudli S, Liebenberg E, Magnitsky S, Miller S, Demir-Deviren S, Lotz JC. Propionibacterium acnes infected intervertebral discs cause vertebral bone marrow lesions consistent with Modic changes. J Orthop Res. 2016 Aug;34(8):1447-55. doi: 10.1002/jor.23265. Epub 2016 Aug 3. PubMed PMID: 27101067.
  • Dudli S, Miller S, Demir-Deviren S, Lotz JC. Inflammatory response of disc cells against Propionibacterium acnes depends on the presence of lumbar modic changes. Eur Spine J. 2018 May;27(5):1013-1020. doi: 10.1007/s00586-017-5291-4. Epub 2017 Sep. PMID: 28884220; PMCID: PMC5842102.
  • Dudli S, Sing DC, Hu SS, Berven SH, Burch S, Deviren V, Cheng I, Tay BKB, Alamin TF, Ith MAM, Pietras EM, Lotz JC. ISSLS PRIZE IN BASIC SCIENCE 2017: Intervertebral disc/bone marrow cross-talk with modic changes. Eur Spine J. 2017 May;26(5):1362-1373. doi: 10.1007/s00586-017-4955-4. Epub 2017 Jan. PMID: 28138783; PMCID: PMC5409869.
  • Fields AJ, Berg-Johansen B, Metz LN, Miller S, La B, Liebenberg EC, Coughlin DG, Graham JL, Stanhope KL, Havel PJ, Lotz JC. Alterations in intervertebral disc composition, matrix homeostasis and biomechanical behavior in the UCD-T2DM rat model of type 2 diabetes. J Orthop Res. 2015 May;33(5):738-46. doi:10.1002/jor.22807. Epub 2015 Mar. PMID: 25641259; PMCID: PMC4408867.
  • Fields AJ, Han M, Krug R, Lotz JC. Cartilaginous end plates: Quantitative MR imaging with very short echo times-orientation dependence and correlation with biochemical composition. Radiology. 2015 Feb;274(2):482-9. doi:10.1148/radiol.14141082. Epub 2014 Oct 10. PubMed PMID: 25302832; PubMed Central PMCID: PMC4314292.
  • Ford AC, Chui WF, Zeng AY, Nandy A, Liebenberg E, Carraro C, Kazakia G, Alliston T, O'Connell GD. A modular approach to creating large engineered cartilage surfaces. J Biomech. 2018 Jan 23;67:177-183. doi: 10.1016/j.jbiomech.2017.11.035. Epub 2017 Dec 9. PubMed PMID: 29273221; PubMed Central PMCID: PMC5767151.
  • Fowler TW, Acevedo C, Mazur CM, Hall-Glenn F, Fields AJ, Bale HA, Ritchie RO, Lotz JC, Vail TP, Alliston T. Glucocorticoid suppression of osteocyte perilacunar remodeling is associated with subchondral bone degeneration in osteonecrosis. Sci Rep. 2017 Mar;7:44618. PMID: 28327602. PMCID: PMC5361115.
  • G.J. Kazakia, J. Carballido-Gamio, A. Lai, L. Nardo, L. Facchetti, C. Pasco, C.A. Zhang, M. Han, A. Hutton Parrott, P. Tien, R. Krug. Trabecular bone microstructure is impaired in the proximal femur of hiv-infected men with normal bone mineral density. 2018; QUIMS 8(1):5-13.
  • Gee CS, Nguyen JT, Marquez CJ, Heunis J, Lai A, Wyatt C, Han M, Kazakia G, Burghardt AJ, Karampinos DC, Carballido-Gamio J, Krug R. Validation of bone marrow fat quantification in the presence of trabecular bone using MRI. J Magn Reson Imaging. 2015 Aug; 42(2):539-44. PMID: 25425074; PMCID: PMC4442769.
  • Gersing AS, Link TM. Imaging of osteoarthritis in geriatric patients. Curr Radiol Rep. 2016 Jan;4(1). pii: 4. Epub 2016 Jan 2. PubMed PMID: 27162704; PubMed Central PMCID: PMC4859342.
  • Gersing AS, Schwaiger BJ, Nevitt MC, Joseph GB, Chanchek N, Guimaraes JB, Mbapte Wamba J, Facchetti L, McCulloch CE, Link TM. Is weight loss associated with less progression of changes in knee articular cartilage among obese and overweight patients as assessed with MR Imaging over 48 Months? Data from the Osteoarthritis Initiative. Radiology. 2017 Aug;284(2):508-520. doi: 10.1148/radiol.2017161005. Epub 2017 May 2. PubMed PMID: 28463057; PubMed Central PMCID: PMC5548450.
  • Gersing AS, Solka M, Joseph GB, Schwaiger BJ, Heilmeier U, Feuerriegel G, Nevitt MC, McCulloch CE, Link TM. Progression of cartilage degeneration and clinical symptoms in obese and overweight individuals is dependent on the  amount of weight loss: 48-month data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2016 Jul;24(7):1126-34. doi: 10.1016/j.joca.2016.01.984. Epub 2016 Jan 30. PubMed PMID: 26828356; PubMed Central PMCID: PMC4907808.
  • Gibbons RS, Beaupre GS, Kazakia GJ. FES-rowing attenuates bone loss following spinal cord injury as assessed by HR-pQCT. Spinal Cord Ser Cases. 2016 Apr 7;2:15041. doi: 10.1038/scsandc.2015.41. eCollection 2016. PubMed PMID: 28053743; PubMed Central PMCID: PMC5129405.
  • Goldman LH, Tang K, Facchetti L, Heilmeier U, Joseph GB, Nevitt MC, McCulloch CE, Souza RB, Link TM. Role of thigh muscle cross-sectional area and strength in progression of knee cartilage degeneration over 48 months - data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2016 Dec;24(12):2082-2091. doi: 10.1016/j.joca.2016.07.004. Epub 2016 Jul 25. PubMed PMID: 27457100; PubMed Central PMCID: PMC5614519.
  • Goodwin AF, Kim R, Bush JO, Klein OD. From bench to bedside and back: improving diagnosis and treatment of craniofacial malformations utilizing animal models. Curr Top Dev Biol. 2015 Jan;115:459-92. doi: 10.1016/bs.ctdb.2015.07.003. Epub 2015 Jan. Review. PMID: 26589935.
  • Hall J, Jheon AH, Ealba EL, Eames BF, Butcher KD, Mak SS, Ladher R, Alliston T, Schneider RA. Evolution of a developmental mechanism: species-specific regulation of the cell cycle and the timing of events during craniofacial osteogenesis. Dev Biol. 2014 Jan;385(2):380-95. PMID: 24262986.
  • Heilmeier U, Cheng K, Pasco C, Parrish R, Nirody J, Patsch JM, Zhang CA, Joseph GB, Burghardt AJ, Schwartz AV, Link TM, Kazakia G. Cortical bone laminar analysis reveals increased midcortical and periosteal porosity in type 2 diabetic postmenopausal women with history of fragility fractures compared to fracture-free diabetics. Osteoporos Int. 2016 Sep; 27(9):2791-2802. PMID: 27154435.
  • Ho L, Wang L, Roth TM, Pan Y, Verdin EM, Hsiao EC, Nissenson RA. Sirtuin-3 promotes adipogenesis, osteoclastogenesis, and bone loss in aging male mice. Endocrinology. 2017 Sep;158(9):2741-2753. PMID: 28911171.
  • Hofmann FC, Neumann J, Heilmeier U, Joseph GB, Nevitt MC, McCulloch CE, Link TM. Conservatively treated knee injury is associated with knee cartilage matrix degeneration measured with MRI-based T2 relaxation times: data from the osteoarthritis initiative. Skeletal Radiol. 2018 Jan;47(1):93-106. doi:10.1007/s00256-017-2759-6. Epub 2017 Aug 29. PubMed PMID: 28852821; PubMed Central PMCID: PMC5699952.
  • Hsiao EC, Millard SM, Nissenson RA. Gs/Gi regulation of bone cell differentiation: review and insights from engineered receptors. Horm Metab Res. 2016 Nov;48(11):689-699. PMID: 27643449.
  • Hu DP, Ferro F, Yang F, Taylor AJ, Chang W, Miclau T, Marcucio RS, Bahney CS. Cartilage to bone transformation during fracture healing is coordinated by the invading vasculature and induction of the core pluripotency genes. Development. 2017 Jan 15; 144(2):221-234. PMID: 28096214.
  • Jáuregui EJ, Akil O, Acevedo C, Hall-Glenn F, Tsai BS, Bale HA, Liebenberg E, Humphrey MB, Ritchie RO, Lustig LR, Alliston T. Parallel mechanisms suppress cochlear bone remodeling to protect hearing. Bone. 2016 Aug;89:7-15. PMID: 27085457.
  • Joo A, Long R, Cheng Z, Alexander C, Chang W, Klein OD. Sprouty2 regulates endochondral bone formation by modulation of RTK and BMP signaling. Bone. 2016 Jul;88:170-9. PMID: 27130872.
  • Joseph GB, Hilton JF, Jungmann PM, Lynch JA, Lane NE, Liu F, McCulloch CE, Tolstykh I, Link TM, Nevitt MC. Do persons with asymmetric hip pain or radiographic hip OA have worse pain and structure outcomes in the knee opposite the more affected hip? Data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2016 Mar;24(3):427-35. doi: 10.1016/j.joca.2015.10.001. Epub 2015 Oct 20. PubMed PMID: 26497607; PubMed Central PMCID: PMC4761312.
  • Joseph GB, Hou SW, Nardo L, Heilmeier U, Nevitt MC, McCulloch CE, Link TM. MRI findings associated with development of incident knee pain over 48 months: data from the osteoarthritis initiative. Skeletal Radiol. 2016 May;45(5):653-60. doi: 10.1007/s00256-016-2343-5. Epub 2016 Feb 27. PubMed PMID: 26919860; PubMed Central PMCID: PMC4815898.
  • Joseph GB, McCulloch CE, Nevitt MC, Gersing AS, Schwaiger BJ, Kretzschmar M, Heilmeier U, Link TM. Medial femur T(2) Z-scores predict the probability of knee structural worsening over 4-8 years: Data from the osteoarthritis initiative. J Magn Reson Imaging. 2017 Oct;46(4):1128-1136. doi: 10.1002/jmri.25662. Epub 2017 Feb 16. PubMed PMID: 28206712; PubMed Central PMCID: PMC5559349.
  • Joseph GB, McCulloch CE, Nevitt MC, Neumann J, Gersing AS, Kretzschmar M, Schwaiger BJ, Lynch JA, Heilmeier U, Lane NE, Link TM. Tool for osteoarthritis risk prediction (TOARP) over 8 years using baseline clinical data, X-ray, and MRI: Data from the osteoarthritis initiative. J Magn Reson Imaging. 2017 Nov 16. doi: 10.1002/jmri.25892. [Epub ahead of print] PubMed PMID: 29143404.
  • Jungmann PM, Baum T, Nevitt MC, Nardo L, Gersing AS, Lane NE,McCulloch CE, Rummeny EJ, Link TM. Degeneration in ACL Injured knees with and without reconstruction in relation to muscle size and fat content-data from the osteoarthritis initiative. PLoS One. 2016 Dec 5;11(12):e0166865. doi: 10.1371/journal.pone.0166865. eCollection 2016. PubMed PMID: 27918596; PubMed Central PMCID: PMC5137877.
  • Kang H, Dang AB, Joshi SK, Halloran B, Nissenson R, Zhang X, Li J, Kim HT, Liu X. Novel mouse model of spinal cord injury-induced heterotopic ossification. J Rehabil Res Dev. 2014 Aug;51(7):1109-18. doi: 10.1682/JRRD.2014.01.0019. PMID: 25436890.
  • Katzman WB, Parimi N, Gladin A, Poltavskiy EA, Schafer AL, Long RK, Fan B, Wong SS, Lane NE. Sex differences in response to targeted kyphosis specific exercise and posture training in community-dwelling older adults: a randomized controlled trial. BMC Musculoskelet Disord. 2017 Dec;18(1):509. PMID: 29202732. PMCID: PMC5715979.
  • Katzman WB, Vittinghoff E, Kado DM, Schafer AL, Wong SS, Gladin A, Lane NE. Study of Hyperkyphosis, Exercise and Function (SHEAF) Protocol of a randomized controlled trial of multimodal spine-strengthening exercise in older adults with hyperkyphosis. Phys Ther. 2016 Mar;96(3):371-81. PMID: 26251480. PMCID: PMC4774389.
  • Katzman WB, Vittinghoff E, Lin F, Schafer A, Long RK, Wong S, Gladin A, Kado DM, Lane NE. Targeted spine strengthening exercise program to reduce hyperkyphosis in older adults: results from the Study of Hyperkyphosis, Exercise, and Function (SHEAF). Osteoporos Int. 2017 Oct;28(10):2831-2841. PMID: 28689306. PMCID: PMC5873977.
  • Kim TY, Schafer AL. Diabetes and bone marrow adiposity. Curr Osteoporos Rep. 2016 Dec;14(6):337-344. Review. PubMed PMID: 27714580; PubMed Central PMCID: PMC5126977.
  • Kim TY, Schwartz AV, Li X, Xu K, Black DM, Petrenko DM, Stewart L, Rogers SJ, Posselt AM, Carter JT, Shoback DM, Schafer AL. Bone marrow fat changes after gastric bypass surgery are associated with loss of bone mass. J Bone Miner Res. 2017 Aug;32(11):2239-2247. PMID: 28791737. PMCID: PMC5685913.
  • Kim W, Takyar FM, Swan K, Jeong J, VanHouten J, Sullivan C, Dann P, Yu H, Fiaschi-Taesch N, Chang W, Wysolmerski J. Calcium-sensing receptor promotes breast cancer by stimulating intracrine actions of parathyroid hormone-related protein. Cancer Res. 2016 Sep;76(18):5348-60. doi: 10.1158/0008-5472.CAN-15-2614. Epub 2016 Jul. PMID: 27450451; PMCID: PMC5026591.
  • Kretzschmar M, Heilmeier U, Yu A, Joseph GB, Liu F, Solka M, McCulloch CE, Nevitt MC, Link TM. Longitudinal analysis of cartilage T2 relaxation times and joint degeneration in African American and  Caucasian American women over an observation period of 6 years – data from the Osteoarthritis Initiative. Osteoarthritis Cartilage. 2016 Aug;24(8):1384-91. doi: 10.1016/j.joca.2016.03.002. Epub 2016 Mar 10. PubMed PMID:26970285; PubMed Central PMCID: PMC4955659.
  • Krug R, Do L, Rieke V, Wilson MW, Saeed M. Evaluation of MRI protocols for the assessment of lumbar facet joints after MR-guided focused ultrasound treatment. J Ther Ultrasound. 2016;4(14). PMCID: PMC482224.
  •  Kumar D, Karampinos DC, MacLeod TD, et al. Quadriceps intramuscular fat fraction rather than muscle size is associated with knee osteoarthritis. Osteoarthritis Cartilage. 2014;22(2):226-34.
  • Laws CJ, Berg-Johansen B, Hargens AR, Lotz JC. The effect of simulated microgravity on lumbar spine biomechanics: an in vitro study. Eur Spine J. 2016 Sep;25(9):2889-97. doi: 10.1007/s00586-015-4221-6. Epub 2015 Sep. PMID: 26403291; PMCID: PMC4808488.
  • Lim M, Otto-Duessel M, He M, Su L, Nguyen D, Chin E, Alliston T, Jones JO. Ligand-independent and tissue-selective androgen receptor inhibition by pyrvinium. ACS Chem Biol. 2014 Mar;9(3):692-702. PMID: 24354286.
  • Link TM, Schwaiger BJ, Zhang AL. Regional articular cartilage abnormalities of the hip. AJR Am J Roentgenol. 2015 Sep;205(3):502-12. doi:10.2214/AJR.15.14463. Review. PubMed PMID: 26295636.
  • Link TM. Editorial comment: the future of compositional MRI for cartilage. EurRadiol. 2018 Apr 30. doi: 10.1007/s00330-018-5457-4. [Epub ahead of print] PubMed PMID: 29713777.
  • Liu X, Ning AY, Chang NC, Kim H, Nissenson R, Wang L, Feeley BT. Investigating the cellular origin of rotator cuff muscle fatty infiltration and fibrosis after injury. Muscles Ligaments Tendons J. 2016 May 19;6(1):6-15. doi: 10.11138/mltj/2016.6.1.006.
    eCollection 2016 Jan-Mar. PubMed PMID: 27331027; PubMed Central PMCID: PMC4915463.
  • Liu X, Kang H, Shahnazari M, Kim H, Wang L, Larm O, Adolfsson L, Nissenson R, Halloran B. A novel mouse model of trauma induced heterotopic ossification. J Orthop Res. 2014 Feb;32(2):183-8. doi: 10.1002/jor.22500. Epub 2013 Oct. PMID: 24136593.
  • Liu X, Ravishankar B, Ning A, Liu M, Kim HT, Feeley BT. Knocking-out matrix metalloproteinase-13 exacerbates rotator cuff muscle fatty infiltration. Muscles Ligaments Tendons J. 2017 Sep;7(2):202-207. doi: 10.11138/mltj/2017.7.2.202. eCollection 2017 Apr-Jun. PMID: 29264329.
  • M. Han, K. Chiba, S. Banerjee, J. Carballido-Gamio, R. Krug. Variable flip angle 3D Fast Spin-Echo MRI combined with outer volume suppression for trabecular bone imaging at the proximal femur. J Magn Reson Imaging. 41(5):1300-10. PMCID: PMC4275424. (2015).
  • M. Han, P.E. Larson, J. Liu, R. Krug. Depiction of Achilles Tendon Microstructure In Vivo Using High-Resolution 3-Dimensional Ultrashort Echo-Time Magnetic Resonance Imaging at 7T. Invest Radiol. 49(5):339-45. PMCID: PMC4143127. (2014).
  • M. Han, V. Rieke, S.J. Scott, E. Ozhinsky, V.A Salgaonkar, P.D. Jones, P.E Z. Larson, C.J. Diederich, R.Krug. Quantifying temperature-dependent T1 changes in cortical bone using ultrashort Echo-Time MRI. Magn Reson Med 74(6); 1548-55. PMCID: PMC4715675. (2015).
  • Magnitsky S, Dudli S, Tang X, Kaur J, Diaz J, Miller S, Lotz JC. Quantification of propionic acid in the bovine spinal disk after infection of the tissue with propionibacteria acnes bacteria. Spine (Phila Pa 1976). 2018 Jun 1;43(11):E634-E638. doi: 10.1097/BRS.0000000000002448. PubMed PMID: 29019804;PubMed Central PMCID: PMC5893447.
  • Miclau KR, Brazina SA, Bahney CS, Hankenson KD, Hunt TK, Marcucio RS, Miclau T. Stimulating Fracture Healing in Ischemic Environments: Does Oxygen Direct Stem Cell Fate during Fracture Healing? Front Cell Dev Biol. 2017 May 4;5:45. doi: 10.3389/fcell.2017.00045. eCollection 2017. Review. PubMed PMID: 28523266; PubMed Central PMCID: PMC5416746.
  • Millard SM, Wang L, Wattanachanya L, O'Carroll D, Fields AJ, Pang J, Kazakia G, Lotz JC, Nissenson RA. Role of osteoblast Gi signaling in age-related bone loss in female mice. Endocrinology. 2017 Jun 01; 158(6):1715-1726. PMID: 28407060.
  • Mohan G, Magnitsky S, Melkus G, Subburaj K, Kazakia G, Burghardt AJ, Dang A, Lane NE, Majumdar S. Kartogenin treatment prevented joint degeneration in a rodent model of osteoarthritis: A pilot study. J Orthop Res. 2016 Oct; 34(10):1780-1789. PMID: 26895619.
  • Napoli N, Schafer AL, Lui LY, Cauley JA, Strotmeyer ES, Le Blanc ES, Hoffman AR, Lee CG, Black DM, Schwartz AV. Serum 25-hydroxyvitamin D level and incident type 2 diabetes in older men, the Osteoporotic Fractures in Men (MrOS) study. Bone. 2016 Sep;90:181-4. PMID: 27393241. PMCID: PMC5466880.
  • Napoli N, Schwartz AV, Schafer AL, Vittinghoff E, Cawthon P, Parimi N, Orwoll E, Strotmeyer ES, Hoffman AR, Barrett-Connor E, Black DM. Vertebral fracture risk in diabetic elderly men: the MrOS Study. J Bone Miner Res. 2018 Jan;33(1):63-69. PMID: 28861910.
  • Nardo L, Karampinos DC, Lansdown DA, et al. Quantitative assessment of fat infiltration in the rotator cuff muscles using water-fat MRI. J Magn Reson Imaging. 2014;39(5):1178-85.
  • Okazaki N, Burghardt AJ, Chiba K, Schafer AL, Majumdar S. Bone microstructure in men assessed by HR-pQCT: associations with risk factors and differences between men with normal, low, and osteoporosis-range areal BMD. Bone Rep. 2016 Dec;5:312-319. PMID: 28580402. PMCID: PMC5440848.
  • Onur TS, Wu R, Chu S, Chang W, Kim HT, Dang AB. Joint instability and cartilage compression in a mouse model of posttraumatic osteoarthritis. J Orthop Res. 2014 Feb;32(2):318-23. doi: 10.1002/jor.22509. Epub 2013 Oct 25. PubMed PMID: 24167068;
    PubMed Central PMCID: PMC4462343.
  • Ouyang A, Cerchiari AE, Tang X, Liebenberg E, Alliston T, Gartner ZJ, Lotz JC. Effects of cell type and configuration on anabolic and catabolic activity in 3D co-culture of mesenchymal stem cells and nucleus pulposus cells. J Orthop Res. 2016 Oct. PMID: 27699833. PMCID: PMC5258652.
  • Ozhinsky E, Han M, Bucknor M, Krug R, Rieke V. T2-based temperature monitoring in bone marrow for MR-guided focused ultrasound. J Ther Ultrasound. 2016; 4:26. PMID: 27882240.
  • Reversal of Fatty Infiltration After Suprascapular Nerve Compression Release Is Dependent on UCP1 Expression in Mice. Clinical orthopaedics and related research. . NIHMSID: NIHMS959671.
  • Riccardi D, Brennan SC, Chang W. The extracellular calcium- sensing receptor, CaSR, in fetal development. Best Pract Res Clin Endocrinol Metab. 2013 Jun;27(3):443-53. doi: 10.1016/j.beem.2013.02.010. Epub 2013 Mar 26. Review. PubMed PMID: 23856271; PubMed Central PMCID: PMC4462341.
  • Saeed, R. Krug, L. Do, SW Hetts, MW Wilson. Renal ablation using magnetic resonance-guided high intensity focused ultrasound: Magnetic resonance imaging and histopathology assessment. World journal of radiology 8(3); 298-307. PMCID: PMC4807339. (2016).
  • Santa Maria C, Cheng Z, Li A, Wang J, Shoback D, Tu CL, Chang W. Interplay between CaSR and PTH1R signaling in skeletal development and osteoanabolism.  Semin Cell Dev Biol. 2016 Jan;49:11-23. doi: 10.1016/j.semcdb.2015.12.004. Epub 2015 Dec. Review. PMID: 26688334; PMCID: PMC4761456.
  • Santa Maria C, Cheng Z, Li A, Wang J, Shoback D, Tu CL, Chang W. Interplay between CaSR and PTH1R signaling in skeletal development and osteoanabolism. Semin Cell Dev Biol. 2016 Jan;49:11-23. doi: 10.1016/j.semcdb.2015.12.004. Epub 2015 Dec10. Review. PubMed PMID: 26688334; PubMed Central PMCID: PMC4761456.
  • Savic D, Pedoia V, Seo Y, Yang J, Bucknor M, Franc BL, Majumdar S. Imaging bone-cartilage interactions in osteoarthritis using [18F]-NaF PET-MRI. Mol Imaging. 2016 01 01; 15:1-12. PMID: 28654417.
  • Schafer AL, Kazakia GJ, Vittinghoff E, Stewart L, Rogers SJ, Kim TY, Carter JT, Posselt AM, Pasco C, Shoback DM, Black DM.  Effects of gastric bypass surgery on bone mass and microarchitecture occur early and particularly impact postmenopausal women. J Bone Miner Res. 2017 Dec. doi: 10.1002/jbmr.3371. [Epub ahead of print] PMID: 29281126.
  • Schafer AL, Li X, Schwartz AV, Tufts LS, Wheeler AL, Grunfeld C, Stewart L, Rogers SJ, Carter JT, Posselt AM, Black DM, Shoback DM. Changes in vertebral bone marrow fat and bone mass after gastric bypass surgery: a pilot study. Bone. 2015 May; 74:140-5. PMID: 25603463. PMCID: PMC4355193.
  • Schafer AL, Weaver CM, Black DM, Wheeler AL, Chang H, Szefc GV, Stewart L, Rogers SJ, Carter JT, Posselt AM, Shoback DM, Sellmeyer DE. Intestinal calcium absorption decreases dramatically after gastric bypass surgery despite optimization of vitamin D status. J Bone Miner Res. 2015 Aug;30(8):1377-85. PMID: 25640580. PMCID: PMC4593653.
  • Schafer AL, Kazakia G, Vittinghoff E, Stewart L, Rogers SJ, Kim TY, Carter JT, Posselt AM, Pasco C, Shoback DM, Black DM. Effects of gastric bypass surgery on bone mass and microarchitecture occur early and particularly impact postmenopausal women. J Bone Miner Res. 2017 Dec 27. PMID: 29281126.
  • Schafer AL. Vitamin D and intestinal calcium transport after bariatric surgery. J Steroid Biochem Mol Biol. 2017 Oct;173:202-210. doi: 10.1016/j.jsbmb.2016.12.012. Epub 2016 Dec 24. Review. PubMed PMID: 28027914; PubMed Central PMCID: PMC5483209.
  • Schultz DS, Rodriguez AG, Hansma PK, Lotz JC. Mechanical profiling of intervertebral discs. J Biomech. 2009 May 29;42(8):1154-7. doi: 10.1016/j.jbiomech.2009.02.013. Epub 2009 Apr 3. PubMed PMID: 19345361; PubMed Central PMCID: PMC3004015.
  • Schwaiger BJ, Gersing AS, Mbapte Wamba J, Nevitt MC, McCulloch CE, Link TM. Can signal abnormalities detected with MR imaging in knee articular cartilage be used to predict development of morphologic cartilage defects? 48-Month Data from the Osteoarthritis Initiative. Radiology. 2016 Oct;281(1):158-67. doi:10.1148/radiol.2016152308. Epub 2016 May 2. PubMed PMID: 27135833; PubMed Central PMCID: PMC5047141.
  • Schwaiger BJ, Mbapte Wamba J, Gersing AS, Nevitt MC, Facchetti L, McCulloch CE, Link TM. Hyperintense signal alteration in the suprapatellar fat pad on MRI is associated with degeneration of the patellofemoral joint over 48 months: data from the Osteoarthritis Initiative. Skeletal Radiol. 2018 Mar;47(3):329-339. doi:10.1007/s00256-017-2771-x. Epub 2017 Sep 24. PubMed PMID: 28944439; PubMed Central PMCID: PMC5871621.
  • Shahnazari M, Turner RT, Iwaniec UT, Wronski TJ, Li M, Ferruzzi MG, Nissenson RA, Halloran BP. Dietary dried plum increases bone mass, suppresses proinflammatory cytokines and promotes attainment of peak bone mass in male mice. J Nutr Biochem. 2016 Aug;34:73-82. PMID: 27239754.
  • Tahimic CG, Long RK, Kubota T, Sun MY, Elalieh H, Fong C, Menendez AT, Wang Y,Vilardaga JP, Bikle DD. Regulation of ligand and shear stress-induced insulin-like growth factor 1 (IGF1) signaling by the integrin pathway. J Biol Chem. 2016 Apr;291(15):8140-9. doi: 10.1074/jbc.M115.693598. Epub 2016 Feb. PMID: 26865633; PMCID: PMC4825016.
  • Tamplen M, Fowler T, Markey J, Knott PD, Suva LJ, Alliston T. Treatment with anti-sclerostin antibody to stimulate mandibular bone formation. Head Neck. 2018 Mar. PMID: 29522281.
  • Tian F, Wang Y, Bikle DD. IGF-1 signaling mediated cell-specific skeletal mechano-transduction. J Orthop Res. 2018 Feb;36(2):576-583. doi: 10.1002/jor.23767. Epub 2017 Nov. Review. PMID: 28980721; PMCID: PMC5839951.
  • Tufts L, Shet Vishnudas K, Fu E, Kurhanewicz J, Ries M, Alliston T, Li X. Correlating high-resolution magic angle spinning NMR spectroscopy and gene analysis in osteoarthritic cartilage. NMR Biomed. 2015 May;28(5):523-8. PMID: 25761416.
  • Wang L, Carroll DO, Liu X, Roth T, Kim H, Halloran B, Nissenson RA. Effects of blockade of endogenous Gi signaling in Tie2-expressing cells on bone formation in a mouse model of heterotopic ossification. J Orthop Res. 2015 Aug;33(8):1212-7. PMID: 25773760.
  • Wang L.*, Hsiao EC*, Lieu S, Scott M., O'Carroll D, Urrutia, A, Conklin, BR, Colnot, C, and Nissenson, RA (2015). Loss of Gi G-protein-coupled receptor signaling in osteoblasts accelerates bone fracture healing. J Bone Miner Res. 2015 Oct;30(10),1896-1904. (* equal contributors). PMID 25917236.
  • Wang T, Wang Y, Menendez A, Fong C, Babey M, Tahimic CG, Cheng Z, Li A, Chang W, Bikle DD. Osteoblast-specific loss of IGF1R signaling results in impaired endochondral bone formation during fracture healing. J Bone Miner Res. 2015 Sep;30(9):1572-84. doi: 10.1002/jbmr.2510. PMID: 25801198; PMCID: PMC5690481.
  • Wang T, Zhang X, Bikle DD. Osteogenic differentiation of periosteal cells during fracture healing. J Cell Physiol. 2017 May;232(5):913-921. doi:10.1002/jcp.25641. Epub 2016 Oct. Review. PMID: 27731505; PMCID: PMC5247290.
  • Wang Y, Menendez A, Fong C, ElAlieh HZ, Chang W, Bikle DD. Ephrin B2/EphB4 mediates the actions of IGF-I signaling in regulating endochondral bone formation. J Bone Miner Res. 2014 Aug;29(8):1900-13. doi: 10.1002/jbmr.2196. PMID: 24677183; PMCID: PMC4108521.
  • Wang Y, Menendez A, Fong C, ElAlieh HZ, Kubota T, Long R, Bikle DD. IGF-I signaling in osterix-expressing cells regulates secondary ossification center formation, growth plate maturation, and metaphyseal formation during postnatal bone development. J Bone Miner Res. 2015 Dec;30(12):2239-48. doi:10.1002/jbmr.2563. Epub 2015 Jul. PMID: 26011431.
  • Wang Z, Feeley B, Kim H, Liu X. Reversal of fatty infiltration after suprascapular nerve compression release is dependent on UCP1 expression in mice. Clinical Orthopaedics and Related Research (Accepted on 12 April 2018).
  • Wattanachanya L, Wang L, Millard SM, Lu WD, O'Carroll, D, Hsiao EC, Conklin BR, and Nissenson RA. (2015). Assessing the osteoblast transcriptome in a model of enhanced bone formation due to constitutive G-G protein signaling in osteoblasts. Exp Cell Res. 2015 May;333(2):289-302. PMCID: PMC4408231.
  • Whitaker AT, Berthet E, Cantu A, Laird DJ, Alliston T. Smad4 regulates growth plate matrix production and chondrocyte polarity. Biol Open. 2017 Mar;6(3):358-364. PMID: 28167493. PMCID: PMC5374397.
  • Yang L, Parimi N, Orwoll ES, Black DM, Schousboe JT, Eastell R. Osteoporotic Fractures in Men (MrOS) Study Research Group. Association of incident hip fracture with the estimated femoral strength by finite element analysis of DXA scans in the Osteoporotic Fractures in Men (MrOS) Study. Osteoporos Int. 2018 Mar;29(3):643-651. doi: 10.1007/s00198-017-4319-2. Epub 2017 Nov. PMID: 29167969.
  • Yang T, Zhang J, Cao Y, Zhang M, Jing L, Jiao K, Yu S, Chang W, Chen D, Wang M. Wnt5a/Ror2 mediates temporomandibular joint subchondral bone remodeling. J Dent Res. 2015 Jun;94(6):803-12. PMID: 25749876.
  • Zhang AL, Sing DC, Dang DY, Ma CB, Black DM, Vail TP, Feeley BT. Overlapping surgery in the ambulatory orthopaedic setting. J Bone Joint Surg Am. 2016 Nov;98(22):1859-1867. PMID: 27852902; PMCID: PMC5125164.
  • Zhang M, Wang H, Zhang J, Zhang H, Yang H, Wan X, Jing L, Lu L, Liu X, Yu S, Chang W, Wang M. Unilateral anterior crossbite induces aberrant mineral deposition in degenerative temporomandibular cartilage in rats. Osteoarthritis Cartilage. 2016 May;24(5):921-31. PMID: 26746151.